# US 2014/0193467 A1 · Compositions comprising tnf-specific antibodies for oral delivery

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- Number: US 2014/0193467 A1
- Document ID: US20140193467A1
- Status: Published application
- Kind: A1
- Application number: 14/152,046
- Filed: 2014-01-10
- Published: 2014-07-10
- Earliest claimed: 2007-10-02
- Assignees: Avaxia Biologics, Incorporated
- Applicants: Avaxia Biologics, Incorporated
- Inventors: Barbara S. Fox
- Web page: https://patentgrep.com/patent/US20140193467A1

## CPC

- C07K 16/241: {Tumor Necrosis Factors}
- A61K 39/3955: {against proteinaceous materials, e.g. enzymes, hormones, lymphokines}
- A61K 2039/505: {comprising antibodies}
- C07K 2317/12: isolated from milk
- C07K 2317/20: characterized by taxonomic origin
- C07K 2317/41: Glycosylation, sialylation, or fucosylation
- C07K 2317/94: Stability, e.g. half-life, pH, temperature or enzyme-resistance
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

In accordance with the invention, the development and use of antibodies within the digestive tract is provided. Antibodies are described that are used to treat disorders associated with altered permeability of the digestive tract. Antibodies are described with increased stability within the environment of the digestive tract. Antibodies are described with enhanced permeability to a compromised digestive tract.

## Claims

### Claim 1

A composition for oral delivery to a human patient comprising anti-TNF antibodies, wherein upon oral administration of the antibodies to the digestive tract of the patient, the antibodies are therapeutically effective to treat inflammatory bowel disease in the patient, and wherein the antibodies are present in the composition at a dosage of about 1 mg per day to about 1 gram per day.

### Claim 2 (depends on 1)

The composition of claim 1, formulated as a solid dosage form for oral administration.

### Claim 3 (depends on 2)

The composition of claim 2, wherein the solid dosage form is selected from capsules, tablets, pills powders and granules.

### Claim 4 (depends on 2)

The composition of claim 2, wherein the solid dosage comprises an enteric coating.

### Claim 5 (depends on 1)

A method of treating inflammatory bowel disease in a human patient comprising orally administering to a patient in need thereof, a composition of claim 1.