# US 2014/0193454 A1 · Method from preparing ceriporia lacerata culture extract and pharmaceutical composition for prevention or treatment of diabetes and diabetic complications comprising ceriporia lacerata culture extract as active ingredient

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- Number: US 2014/0193454 A1
- Document ID: US20140193454A1
- Status: Published application
- Kind: A1
- Application number: 13/737,144
- Filed: 2013-01-09
- Published: 2014-07-10
- Earliest claimed: 2013-01-09
- Inventors: Byoung Cheon KIM
- Web page: https://patentgrep.com/patent/US20140193454A1

## CPC

- A61K 36/07: Basidiomycota, e.g. Cryptococcus
- A61K 2236/00: Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A method for preparing a Ceriporia lacerata mycelium culture extract and a pharmaceutical composition for preventing or treating diabetes and diabetic complications, contains a Ceriporia lacerata mycelium culture extract prepared by the above method. The Ceriporia lacerata mycelium culture extract prepared according to the preparation method of the invention has a higher content of exopolysaccharide than the extract prepared by the method described in the prior art document of the present inventors, and thus it can be used as the active material of pharmaceutical compositions and functional foods against diabetic diseases.

## Claims

### Claim 1

A method for preparing a Ceriporia lacerata mycelium culture extract, the method comprising the steps of: culturing Ceriporia lacerata mycelia in liquid, drying the culture to form powder; and preparing a solvent extract from the powder,
wherein a medium for culturing the Ceriporia lacerata mycelia comprises 1-2 wt % of sugar, 0.2-1 wt % of glucose, 0.2-1 wt % of starch, 0.1-0.5 wt % of sorghum powder, 0.1-0.5 wt % of barley powder, 0.2-2 wt % of soy fluor, 0.05-0.1 wt % of magnesium sulfate (MgSO4), 0.05-0.1 wt % of monopotassium phosphate (KH2PO4) 0.05-0.1 wt % of dipotassium phosphate (K2HPO4) and 92-98 wt % of water and has a pH of 4.5-6.0.

### Claim 2 (depends on 1)

The method of claim 1, wherein the culturing is carried out under a blue LED light source.

### Claim 3 (depends on 1)

The method of claim 1, wherein the culturing is carried out at a carbon dioxide concentration of 1,000-2,000 ppm.

### Claim 4 (depends on 1)

A pharmaceutical composition for preventing or treating diabetes and diabetic complications, which contains, as an active ingredient, a Ceriporia lacerata mycelium culture extract prepared by the method of claim 1.

### Claim 5 (depends on 4)

The pharmaceutical composition of claim 4, wherein the diabetes is type 2 diabetes.

### Claim 6 (depends on 4)

The pharmaceutical composition of claim 4, wherein the diabetic complications are selected from the group consisting of hyperglycemia, atherosclerosis, microangiopathy, diabetic retinopathy and kidney disease.