# US 2014/0193444 A1 · Allergen peptide fragments and use thereof for treatment of dust mite allergies

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- Number: US 2014/0193444 A1
- Document ID: US20140193444A1
- Status: Published application
- Kind: A1
- Application number: 14/206,354
- Filed: 2014-03-12
- Published: 2014-07-10
- Earliest claimed: 2003-03-14
- Assignees: Anergis S.A.
- Applicants: Anergis S.A.
- Inventors: Francois Spertini; Blaise Corthesy
- Web page: https://patentgrep.com/patent/US20140193444A1

## CPC

- A61K 38/168: {from plants}
- A61K 39/35: Allergens
- A61P 11/02: Nasal agents, e.g. decongestants
- A61P 11/06: Antiasthmatics
- A61P 37/04: Immunostimulants
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- C07K 14/415: from plants
- C07K 14/43531: {from mites}
- C07K 14/43563: {from insects}
- C07K 14/43572: {from bees}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

The present invention relates generally to in vivo methods and compositions designed for allergen specific immunotherapy. The compositions include contiguous overlapping peptide fragments which together form an entire amino acid sequence of an allergen.

## Claims

### Claim 1

A composition comprising a plurality of contiguous overlapping peptide fragments 30 to 90 amino acids in length which peptide fragments consist of peptides within SEQ ID NOs: 15 and 16 which together comprise the entire amino acid sequence of a dust mite allergen (SEQ ID NO: 17), wherein said fragments are capable of inducing a T cell response in patients who are hypersensitive to said allergen.