# US 2014/0193384 A1 · Use of lactobacillus for liver protection

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2014/0193384 A1
- Document ID: US20140193384A1
- Status: Published application
- Kind: A1
- Application number: 14/207,528
- Filed: 2014-03-12
- Published: 2014-07-10
- Earliest claimed: 2012-08-29
- Assignees: China Medical University
- Applicants: China Medical University
- Inventors: Wen-Hsin LIN; Chi-Rei WU
- Web page: https://patentgrep.com/patent/US20140193384A1

## CPC

- A61K 35/747: Lactobacilli, e.g. L. acidophilus or L. brevis
- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 1/18: for pancreatic disorders, e.g. pancreatic enzymes
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 3/06: Antihyperlipidemics
- A61P 7/00: Drugs for disorders of the blood or the extracellular fluid
- A61P 35/00: Antineoplastic agents
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23V 2400/169: Plantarum
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A method for liver protection of a mammal is provided and includes administering an effective amount of isolated Lactobacillus plantarum CMU995 thereto. Providing a new use of Lactobacillus plantarum CMU995, which is deposited at the Food Industry Research and Development Institute (FIRDI) in Taiwan under accession number BCRC 910472 and in the German Collection of Microorganisms and Cell Cultures (DSMZ) under accession number DSM 23780.

## Claims

### Claim 1

A probiotic composition for liver protection comprising powdered Lactobacillus plantarum CMU995, wherein the concentration of the powdered Lactobacillus plantarum CMU995 is 1×105 CFU/g to 1×1012 CFU/g, and the Lactobacillus plantarum CMU995 is deposited at the Food Industry Research and Development Institute (FIRDI) in Taiwan under accession number BCRC 910472 and in the German Collection of Microorganisms and Cell Cultures (DSMZ) under accession number DSM 23780.

### Claim 2 (depends on 1)

The probiotic composition according to claim 1, wherein the probiotic composition is in the form of a pharmaceutical composition, a feed, a drink, a nutrient supplement, a diary, a food, or a healthy food.

### Claim 3 (depends on 1)

The probiotic composition according to claim 1, wherein the probiotic composition is used for treating hepatitis caused by alcohol and endotoxin, and reducing endotoxin-induced liver lesions and/or hepatocarcinogenesis.

### Claim 4 (depends on 1)

The probiotic composition according to claim 1 wherein the probiotic composition is in the form of a powder, a tablet, a granule, a suppository, a capsule, an ampoule, a liquid, or a spray.