# US 2014/0193372 A1 · Reducing short-chain fatty acids and energy uptake in obese humans by managing their intestinal microbial communities

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- Number: US 2014/0193372 A1
- Document ID: US20140193372A1
- Status: Published application
- Kind: A1
- Application number: 14/204,757
- Filed: 2014-03-11
- Published: 2014-07-10
- Earliest claimed: 2010-02-16
- Assignees: Arizona Board of Regents for and on behalf of Arizona State University
- Applicants: Arizona Board of Regents for and On Behalf, of Arizona State University
- Inventors: Bruce Rittman; Rosa Krajmalnik-Brown; Husen Zhang; John Dibaise; Michael Crowell
- Web page: https://patentgrep.com/patent/US20140193372A1

## CPC

- A61K 35/741: Probiotics (probiotic yeast, e.g. saccharomyces A61K36/06)
- A61K 31/135: having aromatic rings {, e.g. ketamine, nortriptyline (methadone A61K31/137)}
- A61K 31/185: Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids (hydroxamic acids A61K31/16; peroxy acids A61K31/327)
- A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A61K 35/74: Bacteria (therapeutic use of a bacterial protein A61K38/00)
- A61K 45/00: Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 3/04: Anorexiants; Antiobesity agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides for microbial compositions and methods for reducing the concentration of short-chain fatty acids in the gut as a way to reduce energy uptake and manage obesity. More specifically, the invention provides for decreasing short-chain fatty acids available for absorption in the human gut, such as acetate, using one or more of: a probiotic including a homo-acetogenic, acetate oxidizing bacterium that converts acetate to H2; a probiotic including an acetoclastic methanogen; a microbial electrolysis cell comprising a homo-acetogenic bacterium and/or an acetoclastic methanogen; a prebiotic that enhances the growth or function of acetate-scavenging microbiota; or a highly selective antibiotic that targets H2-oxidizing methanogens.

## Claims

### Claim 1

A composition for decreasing acetate available for absorption in the human gut comprising at least one of the following:
a probiotic comprising an acetoclastic methanogen;
a probiotic comprising a homo-acetogenic, an acetate-oxidizing bacterium that converts acetate to H2;
a miniaturized microbial electrolysis cell comprising an anode-respiring bacterium, that oxidizes acetate and produces H2;
a prebiotic that enhances the growth or function of acetate-scavenging microbiota; or
an antibiotic.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the antibiotic is a selective antibiotic that targets H2-oxidizing methanogens.

### Claim 3 (depends on 1)

A method of managing obesity comprising administering to a patient in need thereof the composition of claim 1.

### Claim 4 (depends on 3)

The method of claim 3, wherein the patient has undergone or will undergo gastric bypass surgery or gastric banding surgery.