# US 2014/0193345 A1 · Herbal compositions for the treatment of mucosal lesions

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- Number: US 2014/0193345 A1
- Document ID: US20140193345A1
- Status: Published application
- Kind: A1
- Application number: 14/206,322
- Filed: 2014-03-12
- Published: 2014-07-10
- Earliest claimed: 2001-05-23
- Assignees: Izun Pharmaceuticals Corp.
- Applicants: Izun Pharmaceuticals Corporation
- Inventors: William Z. LEVINE; Aron J. SAFFER; Mina FRAN
- Web page: https://patentgrep.com/patent/US20140193345A1

## CPC

- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 9/0031: {Rectum, anus}
- A61K 9/006: {Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays}
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 36/23: Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K 36/328: Commiphora, e.g. mecca myrrh or balm of Gilead
- A61K 36/35: Caprifoliaceae (Honeysuckle family)
- A61K 36/38: Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/12: Antivirals
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides therapeutic compositions comprising extracts of the plant species Echinacea purpurea and Sambucus nigra and the extract(s) of at least one further plant selected from the group consisting of Hypericum perforatum, Commiphora molmol and Centella asiatica. The compositions of the invention are of particular utility in the management of inflammatory mucosal diseases of both viral and non-viral origin.

## Claims

### Claim 1

A therapeutic composition comprising extracts of the plant species Echinacea purpurea, Sambucus nigra and Centella asiatica.

### Claim 2 (depends on 1)

A therapeutic composition according to claim 1 for use in the treatment of diseases of the oral mucosa.

### Claim 3 (depends on 1)

A therapeutic composition according to claim 1 for use in the treatment of diseases of the anal mucosa.

### Claim 4 (depends on 1)

A therapeutic composition according to claim 1, further comprising extracts of plants selected from the group consisting of Uncaria tomentosa, Thymus vulgaris, Matricaria recutita, Salix alba, Calendula officinalis, Usnea barbata, Ligusticum porterii-osha, Gaultheria procumbens, Camellia sinensis, Vaccinium myrtillus, Melissa officinalis, Allium sativum, Camellia sinensis and Krameria triandra.

### Claim 5 (depends on 4)

A therapeutic composition according to claim 4, wherein the disease of the oral mucosa to be treated is selected from the group consisting of periodontal disease, gingivitis, aphthous ulceration, mechanical trauma, thermal trauma, lichen planus, bullous pemphigoid, pemphigus vulgaris and dermatitis herpetiformis, angular chelitis and recurrent herpes.

### Claim 6 (depends on 5)

A therapeutic composition according to claim 5, wherein the disease of the anal mucosa to be treated is selected from the group consisting of anal fissures, hemorrhoids and non-specific irritation.

### Claim 7 (depends on 1)

A therapeutic composition according to claim 1 for the inhibition of one or more matrix metalloproteinases.

### Claim 8 (depends on 7)

A therapeutic composition according to claim 7, wherein the one or more matrix metalloproteinases to be inhibited are selected from the group consisting of matrix metalloproteinases 1-9.

### Claim 9 (depends on 8)

A therapeutic composition according to claim 8, wherein the matrix metalloproteinases that are inhibited are of matrix metalloproteinases of subclasses 1, 2, 8 and 9.

### Claim 10 (depends on 9)

A therapeutic composition according to claim 9, wherein the matrix metalloproteinase that is inhibited is of subclass 2.

### Claim 11 (depends on 10)

A therapeutic composition according to claim 10 for use in the treatment of a disease of the oral mucosa selected from the group consisting of periodontal disease and aphthous ulceration.

### Claim 12 (depends on 2)

A therapeutic composition according to claim 2, wherein the disease of the oral mucosa to be treated is selected from the group consisting of periodontal disease, gingivitis, aphthous ulceration, mechanical trauma, thermal trauma, lichen planus, bullous pemphigoid, pemphigus vulgaris, dermatitis herpetiformis, angular chelitis and recurrent herpes.

### Claim 13 (depends on 3)

A therapeutic composition according to claim 3, wherein the disease of the anal mucosa to be treated is selected from the group consisting of anal fissures, hemorrhoids and non-specific irritation.