# US 2014/0193336 A1 · Imaging protocols

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2014/0193336 A1
- Document ID: US20140193336A1
- Status: Published application
- Kind: A1
- Application number: 14/147,682
- Filed: 2014-01-06
- Published: 2014-07-10
- Earliest claimed: 2005-07-19
- Assignees: Biosensors International Group, Ltd.
- Applicants: Biosensors International Group, Ltd.
- Inventors: Benny ROUSSO; Dalia Dickman; Yael Nir; Michael Nagler; Zohar Bronshtine; Shankar Vallabhajosula; Shlomo Ben-Haim; Simona Ben-Haim
- Web page: https://patentgrep.com/patent/US20140193336A1

## CPC

- A61K 51/0476: {complexes from monodendate ligands, e.g. sestamibi}
- A61B 6/503: {for diagnosis of the heart}
- A61B 6/037: {Emission tomography}
- A61B 6/4258: {for detecting non x-ray radiation, e.g. gamma radiation (A61B6/037 takes precedence)}
- G01T 1/1644: {using an array of optically separate scintillation elements permitting direct location of scintillations (G01T1/1645 takes precedence)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G01T: MEASUREMENT OF NUCLEAR OR X-RADIATION (radiation analysis of materials, mass spectrometry G01N23/00; tubes for determining the presence, intensity, density or energy of radiation or particles H01J47/00)

## Abstract

Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence: (a) administering to a subject about 3 mCi Tl201 thallous chloride; (b) allowing said subject to rest; (c) radioimaging a heart of said subject; (d) subjecting said subject to a physical stress; (e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and (f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.

## Claims

### Claim 1

A method of radioimaging a myocardial perfusion, the method comprising in sequence:
(a) administering to a subject about 3 mCi Tc99m sestamibi;
(b) radioimaging a heart of said subject;
(c) subjecting said subject to a pharmacological stress;
(d) administering to said subject at a peak of said pharmacological stress an additional radiopharmaceutical;
(e) radioimaging said heart of said subject; and
(f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.

### Claim 2 (depends on 1)

The method of claim 1, wherein said additional radiopharmaceutical comprises about 3 mCi Tl201 thallous chloride.

### Claim 3 (depends on 1)

The method of claim 1, wherein said additional radiopharmaceutical comprises an additional dose of Tc99m sestamibi.

### Claim 4 (depends on 1)

The method of claim 1, wherein step (b) is effected immediately following step (a).

### Claim 5 (depends on 1)

The method of claim 1, wherein step (b) is within 2 minutes.

### Claim 6 (depends on 1)

The method of claim 1, wherein step (c) is effected immediately following step (b).

### Claim 7 (depends on 1)

The method of claim 1, wherein step (d) is effected within 2 minutes following step (c).

### Claim 8 (depends on 1)

The method of claim 1, wherein step (e) is effected immediately following step (d).

### Claim 9 (depends on 1)

The method of claim 1, wherein step (e) is within 4 minutes.

### Claim 10 (depends on 1)

The method of claim 1, wherein step (f) is effected within 4 hours following step (e).

### Claim 11 (depends on 1)

The method of claim 1, wherein step (f) is within 6 minutes.

### Claim 12 (depends on 1)

The method of claim 1, wherein said pharmacological stress is adenosine or dipyridamole.

### Claim 13 (depends on 1)

The method of claim 1, effected as described in Table 8.

### Claim 14

A method of radioimaging a myocardial perfusion, the method comprising in sequence:
(a) administering to a subject about 0.3 mCi Tl201 thallous chloride;
(b) radioimaging a heart of said subject;
(c) subjecting said subject to a physical stress;
(d) administering to said subject at a peak of said physical stress about 3 mCi Tc99m sestamibi; and
(e) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.

### Claim 15 (depends on 14)

The method of claim 14, wherein step (b) is effected within 10-15 minutes following step (a).

### Claim 16 (depends on 14)

The method of claim 14, wherein step (b) is within 15 minutes.

### Claim 17 (depends on 14)

The method of claim 14, wherein step (c) is immediately following step (b).

### Claim 18 (depends on 14)

The method of claim 14, wherein step (e) is effected within 30-60 minutes following step (d).

### Claim 19 (depends on 14)

The method of claim 14, wherein step (e) is within 15 minutes.

### Claim 20 (depends on 14)

The method of claim 14, effected as described in Table 14.