# US 2014/0192359 A1 · Analyzers with time variation based on color-coded spatial modulation

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- Number: US 2014/0192359 A1
- Document ID: US20140192359A1
- Status: Published application
- Kind: A1
- Application number: 14/155,094
- Filed: 2014-01-14
- Published: 2014-07-10
- Earliest claimed: 2008-02-01
- Assignees: Palo Alto Research Center Incorporated
- Applicants: Palo Alto Research Center Incorporated
- Inventors: Joerg Martini; Peter Kiesel; Malte Huck; Marshall W. Bern; Noble M. Johnson; Michael Bassler; Markus Beck
- Web page: https://patentgrep.com/patent/US20140192359A1

## CPC

- G01N 21/25: Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01J 3/26: using multiple reflection, e.g. Fabry-Perot interferometer, variable interference filters
- G01J 3/28: Investigating the spectrum (using colour filters G01J3/51)
- G01J 3/2803: {using photoelectric array detector}
- G01N 21/05: Flow-through cuvettes (G01N21/09 takes precedence; handling fluid samples G01N1/10)
- G01N 21/255: {Details, e.g. use of specially adapted sources, lighting or optical systems}
- G01N 21/645: {Specially adapted constructive features of fluorimeters}
- G01J 2003/1213: {Filters in general, e.g. dichroic, band}
- G01N 2021/0346: {Capillary cells; Microcells}
- G02B 21/16: adapted for ultraviolet illumination {; Fluorescence microscopes (G02B21/0076 takes precedence)}
- G02B 27/46: Systems using spatial filters
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- G01J: MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY (light sources F21, H01J, H01K, H05B; investigating properties of materials by optical means G01N)
- G02B: OPTICAL ELEMENTS, SYSTEMS OR APPARATUS

## Abstract

A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences. The filter arrangement, in a practical commercial embodiment, can be manufactured to be disposable, and used in a point-of-care device for use practically anywhere, at low cost, and can also be implemented in an in-line monitoring system.

## Claims

### Claim 1

An apparatus, comprising:
a structure that provides for relative motion between an object and a filter assembly, wherein the object is an area within a larger object; and
an encoding component that includes the filter assembly, the filter assembly configured to receive light emanating from objects in the structure;
wherein the filter assembly is adapted to provide output light in response to input light that is within an application's range of photon energies and that is emanating from the object moving relative to the filter assembly;
wherein the filter assembly includes a set of positions, each having a respective transmission function within the range;
wherein the object's relative motion with respect to the filter assembly include at least two segments from which respective positions in the set receive light emanating from the object; and
wherein the filter assembly includes a longitudinal sequence of filter regions, the filter regions including first regions of a first filter type and second regions of a second filter type, the first and second filter types transmitting respective first and second spectral ranges of light, the first and second spectral ranges being sufficiently different from each other that the difference causes time variation in the output light while the object travels through the respective segments.

### Claim at position 2

2-4. (canceled)

### Claim 5 (depends on 1)

The apparatus of claim 1, further comprising:
a source of excitation light configured to illuminate the object and to stimulate the emanating light from the object;
a detector disposed to receive the output light from the filter assembly, the detector adapted to provide a detector output based on the received light; and
a blocking filter disposed between the detector and the flow channel, the blocking filter configured to block the excitation light and to transmit at least a portion of the first and second spectral ranges of light.

### Claim 6

The apparatus of claim, further comprising:
a detector disposed to receive the output light from the filter assembly, the detector adapted to provide a detector output based on the received light.

### Claim 7 (depends on 6)

The apparatus of claim 6, further comprising:
a signal processing unit coupled to the detector to receive the detector output and to provide a system output based on the detector output, the system output providing one or more characteristics of the object.

### Claim at position 6

8-12. (canceled)

### Claim 13 (depends on 1)

The apparatus of claim 1,
wherein the filter assembly further includes opaque regions, at least one opaque region being disposed between two adjacent first regions and at least another opaque region being disposed between two adjacent second regions; and
wherein the opaque regions are arranged in an alternating fashion with at least some of the first regions.

### Claim 14 (depends on 1)

The apparatus of claim 1, wherein at least one of the first regions at least partially overlaps at least one of the second regions to provide a broadened filter region, the broadened filter region transmitting both light of the first spectral range and light of the second spectral range.

### Claim 15

(canceled)

### Claim 16 (depends on 1)

The apparatus of claim 1, wherein the longitudinal sequence of filter regions has a longitudinal length L, wherein the first regions collectively form a first subpattern having a first longitudinal length LA, wherein the second regions collectively form a second subpattern having a second longitudinal length LB, and wherein the first and second subpatterns at least partially overlap such that L<LA+LB.

### Claim 17 (depends on 1)

The apparatus of claim 1, wherein the longitudinal sequence of filter regions has a longitudinal length L, wherein the first regions collectively form a first subpattern having a first longitudinal length LA, wherein the second regions collectively form a second subpattern having a second longitudinal length LB, and wherein the first and second subpatterns do not substantially overlap such that L≧LA+LB.

### Claim 18

A method, comprising:
exciting at least one object such that the object emanates light, the object being an area within a larger object;
causing relative motion between the object and the filter assembly such that light emanating from the excited object is sequentially filtered through a longitudinal sequence of filter regions to provide a filtered output light, the longitudinal sequence of filter regions including first regions of a first filter type and second regions of a second filter type, the first and second filter types transmitting respective first and second spectral ranges of light, the first and second spectral ranges of the respective filter regions being sufficiently different from each other that the difference causes a time variation in the filtered output light;
detecting the filtered output light and providing a time-varying detector output as a function of the detected light; and
analyzing the time-varying detector output to provide one or more characteristics of the object.

### Claim 19 (depends on 18)

The method of claim 18, wherein the analyzing includes evaluating frequency content of the time-varying detector output to measure frequency component magnitudes at a plurality of frequencies, and to provide the one or more characteristics of the object based on the measured frequency component magnitudes.

### Claim 20 (depends on 19)

The method of claim 19, wherein the analyzing includes comparing at least a first and second one of the measured frequency component magnitudes.

### Claim 21 (depends on 18)

The method of claim 18, wherein the analyzing includes identifying one or more peaks in a frequency spectrum of the time-varying detector output.

### Claim 22 (depends on 21)

The method of claim 21, wherein identifying one or more peaks includes identifying a dominant peak in the frequency spectrum, and measuring coordinates of the dominant peak, including a first frequency of the dominant peak and a first frequency component magnitude of the dominant peak.

### Claim at position 17

23-26. (canceled)

### Claim 27 (depends on 18)

The method of claim 18, wherein the analyzing includes correlating the time varying detector output to an additional signal to produce a correlation result.

### Claim 28 (depends on 27)

The method of claim 27, wherein the additional signal comprises a template.

### Claim 29 (depends on 28)

The method of claim 28, further comprising calculating a derivative with respect to time of the correlation result.

### Claim 30

A method of using a filter arrangement, the method comprising:
during relative movement between an object and the filter arrangement, the object emanating light within an application's range of photon energies and transmitting/reflecting at least some of the emanating light through the filter arrangement;
the act of transmitting/reflecting at least some of the emanating light through the filter arrangement producing time variation in the emanating light that includes information about characteristics of the object, wherein the object is a color area within a larger object, the act of transmitting/reflecting including at least one of:
transmitting/reflecting respective portions of the emanating light through respective positions of a filter assembly within the filter arrangement; two of the positions that are adjacent having respective transmission functions sufficiently different from each other that the difference causes time variation in the emanating light between the respective segments; and
transmitting/reflecting a respective portion of the emanating light through a filter component within the filter arrangement; the filter component having a combined transmission function in which a set of two or more simpler transmission functions is superimposed; the set including first and second simpler non-uniform transmission functions, the set being superimposed such that time variation occurs in the emanating light in accordance with superposition of the first and second simpler nonuniform transmission functions.

### Claim 31 (depends on 27)

The method of claim 27, further comprising distinguishing the object from other objects based on the information.

### Claim 32

An apparatus comprising:
an encoding component, the encoding component including a filter arrangement that can receive light emanating from objects in response to input light that is within an application's range of photon energies and that is emanating from an object during relative motion between the object and the filter arrangement, the filter arrangement providing output light that includes information about one or more characteristics of the object wherein the object is a colored area within a larger object;
the filter arrangement including at least one of:
a filter assembly that includes a set of positions, each having a respective transmission function within the range; a series of segments of an object's relative motion including at least two segments from which respective positions in the set receive light emanating from the object, two of the respective positions that are adjacent having respective transmission functions sufficiently different from each other that the difference causes time variation in the output light while the object travels through the respective segments; and
a filter component that receives input light from a segment of an object and that, within the range, has a combined transmission function in which a set of two or more simpler transmission functions is superimposed; the set including first and second simpler non-uniform transmission functions, the set being superimposed such that time variation occurs in the output light in accordance with superposition of the first and second simpler non-uniform transmission functions while the object travels through the segment.

### Claim 33 (depends on 32)

The apparatus of claim 32 wherein the filter arrangement includes at least one of:
an absorption filter;
an interference-based filter;
a light-transmissive and/or light-reflective filter;
a longitudinal sequence of filters that vary in a periodic,
random, or chirped pattern;
filter elements of two or more colors;
filter elements of two or more gray levels;
overlapping filter elements;
a longitudinal sequence of filter elements that includes
binary, gray level, and color filter elements;
two or more lengthwise extending filter elements;
a radial sequence of filter elements;
two orthogonally striped filter assemblies;
filter assemblies on opposite sides of a fluidic channel; and
a stack-equivalent filter.

### Claim 34 (depends on 32)

The apparatus of claim 32, wherein the information comprises color of the object.

### Claim 35 (depends on 32)

The apparatus of claim 32, wherein the information comprises differences in color emanating from the object.

### Claim 36

An article of manufacture, comprising:
a structure, wherein excitation light enters the structure and interacts with an object resulting in emanating light; and
one or more mask arrangements configured to receive at least part of the emanating light and in response, provide encoded emanating light,
wherein the one or more mask arrangements and the channel are further configured so that the encoded emanating light includes time variation resulting from relative movement between the one or more mask arrangements and the object, the time variation including information the object, wherein the object comprises an area within a larger object; and
a photo-sensor configured to receive the encoded emanating light and detect time variation resulting from relative movement between the one or more mask arrangements and the objects, and wherein the photo-sensor is further configured to provide an electrical signal indicating one or more sensed time-varying waveforms.