# US 2014/0190890 A1 · Collection system for purification flowstreams

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- Number: US 2014/0190890 A1
- Document ID: US20140190890A1
- Status: Published application
- Kind: A1
- Application number: 14/085,387
- Filed: 2013-11-20
- Published: 2014-07-10
- Earliest claimed: 2008-11-12
- Assignees: Waters Technologies Corporation
- Inventors: Harbaksh Sidhu; Ziqiang Wang; Steven L. Zulli
- Web page: https://patentgrep.com/patent/US20140190890A1

## CPC

- B01D 15/10: characterised by constructional or operational features
- G01N 30/82: Automatic means therefor
- G01N 30/02: Column chromatography
- G01N 2030/324: {speed, flow rate}
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A collection system for collecting samples from a flowstream (5) exiting a supercritical fluid chromatography system is provided. The collection system comprises: (i) a first back pressure regulator (10) on the flowstream as it exits the chromatography system, (ii) a gas-liquid separator (30) having a tapered and angled dripper (65), which introduces the flow into the separator at an angle tangential to the separator wall; and (iii) one or more fraction collectors (15), wherein the fraction collector is at a reduced pressure collection point, between 100 bar and atmospheric pressure. A collection system for HPLC is also provided, as well as a process for collection of samples from a flowstream.

## Claims

### Claim 1

A process for collecting samples in a flow stream from a supercritical fluid chromatography system, the flowstream having gas and liquid components, the process comprising the steps of:
i) reducing the pressure of the flow stream to a pressure between system pressure and atmospheric pressure;
ii) optionally, heating the flow stream;
iii) separating the gas and liquid components in a separator having a tapered and angled dripper which introduces the flow to the separator at an angle tangential to the separator wall; and
iv) collecting the samples in collection vessels which are at a pressure between atmospheric pressure up to a pressure below system pressure.

### Claim 2 (depends on 1)

The process of claim 1, wherein the separator is maintained at a pressure below system pressure.

### Claim 3 (depends on 1)

The process of claim 1, wherein the separator is maintained at a pressure of about 1 bar to about 100 bar.

### Claim 4 (depends on 1)

The process of claim 1, wherein the angle of the dripper is between 10 and 80 degrees from vertical.

### Claim 5 (depends on 1)

The process of claim 1, wherein the ratio of the volume of the separator to the volume of the dripper is between about 10 and 1000 to one.

### Claim 6 (depends on 1)

The process of claim 1, wherein the ratio of the diameter of the dripper outlet to the diameter of the dripper inlet is between 2 and 100.

### Claim 7 (depends on 1)

The process of claim 1, wherein the flow rate of the flow stream is between 10 and 1000 gm/minute.

### Claim 8 (depends on 1)

The process of claim 1, further comprising the step of heating the flow stream.

### Claim 9 (depends on 8)

The process of claim 8, wherein the heated flow stream is maintained at a temperature of about 25° C. to about 100° C.