# US 2014/0190854 A1 · Foamable composition essentially free of pharmaceutically active ingredients for the treatment of human skin

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- Number: US 2014/0190854 A1
- Document ID: US20140190854A1
- Status: Published application
- Kind: A1
- Application number: 14/142,039
- Filed: 2013-12-27
- Published: 2014-07-10
- Earliest claimed: 2008-12-23
- Assignees: Intendis GmbH
- Applicants: Intendis GmbH
- Inventors: Klaus Graupe; Gerald Stadtler
- Web page: https://patentgrep.com/patent/US20140190854A1

## CPC

- A61K 8/046: {Aerosols; Foams}
- A61K 8/342: {Alcohols having more than seven atoms in an unbroken chain}
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings
- A61K 8/375: {the alcohol moiety containing more than one hydroxy group}
- A61K 8/4973: {with oxygen as the only hetero atom}
- A61K 8/4993: {Derivatives containing from 2 to 10 oxyalkylene groups}
- A61K 8/73: Polysaccharides
- A61K 8/731: {Cellulose; Quaternized cellulose derivatives}
- A61K 8/86: Polyethers
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/122: {Foams; Dry foams (edible foams A61K9/0056)}
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 17/04: Antipruritics
- A61P 17/06: Antipsoriatics
- A61P 17/10: Anti-acne agents
- A61P 17/16: Emollients or protectives, e.g. against radiation
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/005: {Preparations for sensitive skin}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention related to the use of a pharmaceutical composition which is essentially free of pharmaceutically active ingredients for the treatment of human skin, especially in the treatment of rosacea, acne, atopic dermatitis, contact dermatitis, perioral dermatitis, psoriasis or neurodermitis, as well as for prophylactic and/or cosmetic purposes.

## Claims

### Claim 1

A method for applying a cosmetic product to the skin, comprising topically Use of a foamable composition essentially free of pharmaceutically active ingredients, consisting of:
10.00-12.00 g/100 g
Caprylic/capric triglyceride
0.90-1.20 g/100 g
Cetostearyl alcohol
0.44-0.70 g/100 g
Glyceryl stearate
0.10-0.15 g/100 g
Benzoic acid
2.50-3.00 g/100 g
PEG-40 stearate
0.08-0.20 g/100 g
Methylcellulose
0.20-0.32 g/100 g
Xanthan gum
0.90-1.20 g/100 g
Polysorbate 80
5.35-6.00 g/100 g
Dimethyl isosorbide
10.87-12.25 g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
7.00-9.00 g
Propellant blend
in a container with an outlet valve.

### Claim 2 (depends on 1)

A method a foamable composition essentially free of pharmaceutically active ingredients according to claim 1, wherein said foamable composition consists of
10.00 g/100 g
Caprylic/capric triglyceride
1.20 g/100 g
Cetostearyl alcohol
0.44 g/100 g
Glyceryl stearate
0.10 g/100 g
Benzoic acid
3.00 g/100 g
PEG-40 stearate
0.08 g/100 g
Methylcellulose
0.20 g/100 g
Xanthan gum
1.00 g/100 g
Polysorbate 80
5.35 g/100 g
Dimethyl isosorbide
12.00 g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
8.00 g
Propellant blend
or consists of
10.87 g/100 g
Caprylic/capric triglyceride
1.09 g/100 g
Cetostearyl alcohol
0.54 g/100 g
Glyceryl stearate
0.10 g/100 g
Benzoic acid
2.83 g/100 g
PEG-40 stearate
0.11 g/100 g
Methylcellulose
0.27 g/100 g
Xanthan gum
0.98 g/100 g
Polysorbate 80
5.44 g/100 g
Dimethyl isosorbide
10.87 g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
8.00 g
Propellant blend
or consists of
11.10 g/100 g
Caprylic/capric triglyceride
0.90 g/100 g
Cetostearyl alcohol
0.60 g/100 g
Glyceryl stearate
0.11 g/100 g
Benzoic acid
2.50 g/100 g
PEG-40 stearate
0.15 g/100 g
Methylcellulose
0.25 g/100 g
Xanthan gum
0.90 g/100 g
Polysorbate 80
5.75 g/100 g
Dimethyl isosorbide
11.80 g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
7.00 g
Propellant blend
or consists of
12.00 g/100 g
Caprylic/capric triglyceride
1.00 g/100 g
Cetostearyl alcohol
0.55 g/100 g
Glyceryl stearate
0.12 g/100 g
Benzoic acid
2.60 g/100 g
PEG-40 stearate
0.18 g/100 g
Methylcellulose
0.30 g/100 g
Xanthan gum
0.95 g/100 g
Polysorbate 80
6.00 g/100 g
Dimethyl isosorbide
12.25 g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
9.00 g
Propellant blend
or consists of
11.50 g/100 g
Caprylic/capric triglyceride
1.20 g/100 g
Cetostearyl alcohol
0.70 g/100 g
Glyceryl stearate
0.15 g/100 g
Benzoic acid
2.95 g/100 g
PEG-40 stearate
0.20 g/100 g
Methylcellulose
0.32 g/100 g
Xanthan gum
1.20 g/100 g
Polysorbate 80
5.90 g/100 g
Dimethyl isosorbide
11.50 g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
8.50 g
Propellant blend

### Claim 3 (depends on 1)

A method according to claim 1, wherein the propellant is butane, propane, isobutene, dimethylether, fluorocarbon gases or a mixture thereof.

### Claim at position 4

4 A container with an outlet valve filled with a foamable composition essentially free of pharmaceutically active ingredients, said foamable composition consisting of:
10.00-12.00 g/100 g
Caprylic/capric triglyceride
0.90-1.20 g/100 g
Cetostearyl alcohol
0.44-0.70 g/100 g
Glyceryl stearate
0.10-0.15 g/100 g
Benzoic acid
2.50-3.00 g/100 g
PEG-40 stearate
0.08-0.20 g/100 g
Methylcellulose
0.20-0.32 g/100 g
Xanthan gum
0.90-1.20 g/100 g
Polysorbate 80
5.35-6.00 g/100 g
Dimethyl isosorbide
10.87-12.25 g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
7.00-9.00 g
Propellant blend

### Claim 5 (depends on 4)

A container according to claim 4, wherein said foamable composition consists of
10.00
g/100 g
Caprylic/capric triglyceride
1.20
g/100 g
Cetostearyl alcohol
0.44
g/100 g
Glyceryl stearate
0.10
g/100 g
Benzoic acid
3.00
g/100 g
PEG-40 stearate
0.08
g/100 g
Methylcellulose
0.20
g/100 g
Xanthan gum
1.00
g/100 g
Polysorbate 80
5.35
g/100 g
Dimethyl isosorbide
12.00
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
8.00
g
Propellant blend
or consists of
10.87
g/100 g
Caprylic/capric triglyceride
1.09
g/100 g
Cetostearyl alcohol
0.54
g/100 g
Glyceryl stearate
0.10
g/100 g
Benzoic acid
2.83
g/100 g
PEG-40 stearate
0.11
g/100 g
Methylcellulose
0.27
g/100 g
Xanthan gum
0.98
g/100 g
Polysorbate 80
5.44
g/100 g
Dimethyl isosorbide
10.87
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
8.00
g
Propellant blend
or consists of
11.10
g/100 g
Caprylic/capric triglyceride
0.90
g/100 g
Cetostearyl alcohol
0.60
g/100 g
Glyceryl stearate
0.11
g/100 g
Benzoic acid
2.50
g/100 g
PEG-40 stearate
0.15
g/100 g
Methylcellulose
0.25
g/100 g
Xanthan gum
0.90
g/100 g
Polysorbate 80
5.75
g/100 g
Dimethyl isosorbide
11.80
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
7.00
g
Propellant blend
or consists of
12.00
g/100 g
Caprylic/capric triglyceride
1.00
g/100 g
Cetostearyl alcohol
0.55
g/100 g
Glyceryl stearate
0.12
g/100 g
Benzoic acid
2.60
g/100 g
PEG-40 stearate
0.18
g/100 g
Methylcellulose
0.30
g/100 g
Xanthan gum
0.95
g/100 g
Polysorbate 80
6.00
g/100 g
Dimethyl isosorbide
12.25
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
9.00
g
Propellant blend
or consists of
11.50
g/100 g
Caprylic/capric triglyceride
1.20
g/100 g
Cetostearyl alcohol
0.70
g/100 g
Glyceryl stearate
0.15
g/100 g
Benzoic acid
2.95
g/100 g
PEG-40 stearate
0.20
g/100 g
Methylcellulose
0.32
g/100 g
Xanthan gum
1.20
g/100 g
Polysorbate 80
5.90
g/100 g
Dimethyl isosorbide
11.50
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
8.50
g
Propellant blend.

### Claim 6 (depends on 4)

A container according to claim 4, wherein the propellant is butane, propane, isobutene, dimethylether, fluorocarbon gases or a mixture thereof.

### Claim 7 (depends on 2)

A method according to claim 2, wherein the propellant is butane, propane, isobutene, dimethylether, fluorocarbon gases or a mixture thereof.

### Claim 8 (depends on 5)

A container according to claim 5, wherein the propellant is butane, propane, isobutene, dimethylether, fluorocarbon gases or a mixture thereof.

### Claim 9 (depends on 2)

A method according to claim 2, wherein said foamable composition consists of
10.00
g/100 g
Caprylic/capric triglyceride
1.20
g/100 g
Cetostearyl alcohol
0.44
g/100 g
Glyceryl stearate
0.10
g/100 g
Benzoic acid
3.00
g/100 g
PEG-40 stearate
0.08
g/100 g
Methylcellulose
0.20
g/100 g
Xanthan gum
1.00
g/100 g
Polysorbate 80
5.35
g/100 g
Dimethyl isosorbide
12.00
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
8.00
g
Propellant blend.

### Claim 10 (depends on 2)

A method according to claim 2, wherein said foamable composition consists of
10.87
g/100 g
Caprylic/capric triglyceride
1.09
g/100 g
Cetostearyl alcohol
0.54
g/100 g
Glyceryl stearate
0.10
g/100 g
Benzoic acid
2.83
g/100 g
PEG-40 stearate
0.11
g/100 g
Methylcellulose
0.27
g/100 g
Xanthan gum
0.98
g/100 g
Polysorbate 80
5.44
g/100 g
Dimethyl isosorbide
10.87
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
8.00
g
Propellant blend.

### Claim 11 (depends on 2)

A method according to claim 2, wherein said foamable composition consists of
11.10
g/100 g
Caprylic/capric triglyceride
0.90
g/100 g
Cetostearyl alcohol
0.60
g/100 g
Glyceryl stearate
0.11
g/100 g
Benzoic acid
2.50
g/100 g
PEG-40 stearate
0.15
g/100 g
Methylcellulose
0.25
g/100 g
Xanthan gum
0.90
g/100 g
Polysorbate 80
5.75
g/100 g
Dimethyl isosorbide
11.80
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
7.00
g
Propellant blend.

### Claim 12 (depends on 2)

A method according to claim 2, wherein said foamable composition consists of
12.00
g/100 g
Caprylic/capric triglyceride
1.00
g/100 g
Cetostearyl alcohol
0.55
g/100 g
Glyceryl stearate
0.12
g/100 g
Benzoic acid
2.60
g/100 g
PEG-40 stearate
0.18
g/100 g
Methylcellulose
0.30
g/100 g
Xanthan gum
0.95
g/100 g
Polysorbate 80
6.00
g/100 g
Dimethyl isosorbide
12.25
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
9.00
g
Propellant blend.

### Claim 13 (depends on 2)

A method according to claim 2, wherein said foamable composition consists of
11.50
g/100 g
Caprylic/capric triglyceride
1.20
g/100 g
Cetostearyl alcohol
0.70
g/100 g
Glyceryl stearate
0.15
g/100 g
Benzoic acid
2.95
g/100 g
PEG-40 stearate
0.20
g/100 g
Methylcellulose
0.32
g/100 g
Xanthan gum
1.20
g/100 g
Polysorbate 80
5.90
g/100 g
Dimethyl isosorbide
11.50
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
8.50
g
Propellant blend.

### Claim 14 (depends on 5)

A container according to claim 5, wherein said foamable composition consists of
10.00
g/100 g
Caprylic/capric triglyceride
1.20
g/100 g
Cetostearyl alcohol
0.44
g/100 g
Glyceryl stearate
0.10
g/100 g
Benzoic acid
3.00
g/100 g
PEG-40 stearate
0.08
g/100 g
Methylcellulose
0.20
g/100 g
Xanthan gum
1.00
g/100 g
Polysorbate 80
5.35
g/100 g
Dimethyl isosorbide
12.00
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
8.00
g
Propellant blend.

### Claim 15 (depends on 5)

A container according to claim 5, wherein said foamable composition consists of
10.87
g/100 g
Caprylic/capric triglyceride
1.09
g/100 g
Cetostearyl alcohol
0.54
g/100 g
Glyceryl stearate
0.10
g/100 g
Benzoic acid
2.83
g/100 g
PEG-40 stearate
0.11
g/100 g
Methylcellulose
0.27
g/100 g
Xanthan gum
0.98
g/100 g
Polysorbate 80
5.44
g/100 g
Dimethyl isosorbide
10.87
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
8.00
g
Propellant blend.

### Claim 16 (depends on 5)

A container according to claim 5, wherein said foamable composition consists of
11.10
g/100 g
Caprylic/capric triglyceride
0.90
g/100 g
Cetostearyl alcohol
0.60
g/100 g
Glyceryl stearate
0.11
g/100 g
Benzoic acid
2.50
g/100 g
PEG-40 stearate
0.15
g/100 g
Methylcellulose
0.25
g/100 g
Xanthan gum
0.90
g/100 g
Polysorbate 80
5.75
g/100 g
Dimethyl isosorbide
11.80
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
7.00
g
Propellant blend.

### Claim 17 (depends on 5)

A container according to claim 5, wherein said foamable composition consists of
12.00
g/100 g
Caprylic/capric triglyceride
1.00
g/100 g
Cetostearyl alcohol
0.55
g/100 g
Glyceryl stearate
0.12
g/100 g
Benzoic acid
2.60
g/100 g
PEG-40 stearate
0.18
g/100 g
Methylcellulose
0.30
g/100 g
Xanthan gum
0.95
g/100 g
Polysorbate 80
6.00
g/100 g
Dimethyl isosorbide
12.25
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
9.00
g
Propellant blend.

### Claim 18 (depends on 5)

A container according to claim 5, wherein said foamable composition consists of
11.50
g/100 g
Caprylic/capric triglyceride
1.20
g/100 g
Cetostearyl alcohol
0.70
g/100 g
Glyceryl stearate
0.15
g/100 g
Benzoic acid
2.95
g/100 g
PEG-40 stearate
0.20
g/100 g
Methylcellulose
0,32
g/100 g
Xanthan gum
1.20
g/100 g
Polysorbate 80
5.90
g/100 g
Dimethyl isosorbide
11.50
g/100 g
Propylene glycol
to pH 4.5
Sodium hydroxide
ad 100
Purified water
8.50
g
Propellant blend.