# US 2014/0190496 A1 · Methods and devices for compound delivery > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0190496 A1 - Document ID: US20140190496A1 - Status: Published application - Kind: A1 - Application number: 14/092,405 - Filed: 2013-11-27 - Published: 2014-07-10 - Earliest claimed: 2012-11-28 - Assignees: E-Nicotine Technology, Inc. - Applicants: E-Nicotine Technology, Inc. - Inventors: Martin Wensley; Michael Hufford; Jeffrey Williams; Peter Lloyd - Web page: https://patentgrep.com/patent/US20140190496A1 ## CPC - A61M 15/0065: {Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52)} - A24B 15/167: in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes - A24F 40/485: Valves; Apertures - A61M 11/001: {Particle size control} - A61M 11/041: {using heaters} - A61M 11/042: {electrical} - A61M 15/06: Inhaling appliances shaped like cigars, cigarettes or pipes - A24F 40/10: Devices using liquid inhalable precursors - A61M 11/002: {by flow deviation causing inertial separation of transported particles} - A61M 15/002: {with air flow regulating means} - A61M 15/0066: {with means for varying the dose size} - A61M 15/0083: {Timers} - A61M 16/0066: {Blowers or centrifugal pumps} - A61M 2016/0015: {inhalation detectors} - A61M 2016/0021: {with a proportional output signal, e.g. from a thermistor} - A61M 2205/3553: remote, e.g. between patient's home and doctor's office - A61M 2205/3561: local, e.g. within room or hospital - A61M 2205/3569: sublocal, e.g. between console and disposable - A61M 2205/3584: using modem, internet or Bluetooth® - A61M 2205/3592: using telemetric means, e.g. radio or optical transmission - A61M 2205/3653: by Joule effect, i.e. electric resistance - A61M 2205/502: User interfaces, e.g. screens or keyboards - A61M 2205/52: with memories providing a history of measured variating parameters of apparatus or patient - A61M 2205/8206: battery-operated - A61M 2206/14: Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws - Y02A 90/10: Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A24B: MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF - A24F: SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES (inhaling appliances for medical purposes, shaped like cigars, cigarettes or pipes A61M15/06) - Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE ## Abstract Provided herein are methods, devices, systems, and computer readable medium for delivering one or more compounds to a subject. Also described herein are methods, devices, systems, and computer readable medium for transitioning a smoker to an electronic nicotine delivery device and for smoking or nicotine cessation. ## Claims ### Claim 1 A condensation aerosol generating device for generating a condensation aerosol of a liquid formulation, the device comprising: a. a reservoir comprising a liquid formulation; and b. a passageway comprising a heater element, wherein the reservoir is in fluid communication with the heater element, wherein the heater element is capable of vaporizing the liquid formulation when the liquid formulation is delivered onto the heater element, and wherein a flow of air through the passageway condenses the vaporized liquid formulation into particles having a mass median aerodynamic diameter (MMAD) of from about 1 μm to about 5 μm. ### Claim 2 (depends on 1) The device of claim 1, wherein the device is configured to produce an internal air resistance of from about 0.08 to about 0.12 sqrt (cm-H2O)/LPM. ### Claim 3 (depends on 1) The device of claim 1, wherein the passageway comprises an upstream opening and a downstream opening, wherein the upstream opening comprises an inlet for the air and the downstream opening serves as an outlet for air. ### Claim 4 (depends on 3) The device of claim 3, wherein the heater element is located within the passageway between the upstream and downstream openings. ### Claim 5 (depends on 3) The device of claim 3, wherein the reservoir is located within the passageway between the upstream and downstream openings. ### Claim 6 (depends on 3) The device of claim 3, further comprising an air flow regulator located in the passageway. ### Claim 7 (depends on 6) The device of claim 6, further comprising a second passageway, wherein the air flow regulator is capable of directing air through the second passageway in response to a pressure drop across the air flow regulator. ### Claim 8 (depends on 8) The device of claim 8, wherein the air flow regulator comprises one or more gas control valves. ### Claim 9 (depends on 1) The device of claim 1, wherein the heater element comprises a wire coil. ### Claim 10 (depends on 1) The device of claim 1, further comprising a capillary in fluid communication with the reservoir. ### Claim 11 (depends on 10) The device of claim 10, wherein the capillary is in fluid communication with the heater element. ### Claim 12 (depends on 10) The device of claim 10, wherein the capillary comprises a heatable region. ### Claim 13 (depends on 12) The device of claim 12, further comprising a check valve located in the capillary between the heatable region and the reservoir. ### Claim 14 (depends on 1) The device of claim 1, further comprising a controller, wherein the controller comprises a non-transitory computer readable medium comprising one or more algorithms, wherein the one or more algorithms regulate dosing or a delivery schedule of the condensation aerosol of the liquid formulation. ### Claim 15 (depends on 14) The device of claim 14, further comprising an interface for communicating with the controller. ### Claim 16 (depends on 14) The device of claim 14, wherein the controller is removably attached to the passageway and the reservoir. ### Claim 17 (depends on 14) The device of claim 14, wherein the controller is capable of communicating with one or more electronic devices. ### Claim 18 (depends on 1) The device of claim 1, wherein the liquid formulation comprises a flavoring. ### Claim 19 A condensation aerosol generating device for generating a condensation aerosol of a liquid formulation, the device comprising: a. a passageway comprising a heater element; and b. a reservoir comprising the liquid formulation, wherein the reservoir is in fluid communication with the heater element, wherein the heater element is capable of vaporizing the liquid formulation when the liquid formulation is delivered onto the heater element, and wherein a flow of air through the device delivers the condensation aerosol of the liquid formulation to the deep lung of a subject using the device. ### Claim 20 (depends on 19) The device of claim 19, wherein the device permits a flow resistance of from about 0.08 to about 0.12 sqrt (cm-H2O)/LPM. ### Claim 21 (depends on 19) The device of claim 19, wherein the passageway comprises an upstream opening and a downstream opening, wherein the upstream opening comprises an inlet for the air and the downstream opening serves as an outlet for the air, and wherein the heater element is located in the passageway between the upstream and downstream openings. ### Claim 22 (depends on 19) The device of claim 19, wherein the reservoir is located within the passageway between the upstream and downstream openings. ### Claim 23 (depends on 19) The device of claim 19, further comprising an air flow regulator located in the passageway. ### Claim 24 (depends on 23) The device of claim 23, further comprising a second passageway, wherein the air flow regulator is capable of directing the air through the second passageway in response to a pressure drop across the air flow regulator. ### Claim 25 (depends on 24) The device of claim 24, wherein the air flow regulator comprises one or more gas control valves. ### Claim 26 (depends on 19) The device of claim 19, wherein the heater element comprises a wire coil. ### Claim 27 (depends on 19) The device of claim 19, further comprising a capillary in fluid communication with the reservoir. ### Claim 28 (depends on 27) The device of claim 27, wherein the capillary is in fluid communication with the heater element. ### Claim 29 (depends on 27) The device of claim 27, wherein the capillary comprises a heatable region. ### Claim 30 (depends on 19) The device of claim 19, further comprising a controller, wherein the controller comprises a non-transitory computer readable medium comprising one or more algorithms wherein the one or more algorithms regulate dosing or a delivery schedule of the condensation aerosol of the liquid formulation. ### Claim 31 (depends on 30) The device of claim 30, further comprising an interface for communicating with the controller. ### Claim 32 (depends on 30) The device of claim 30, wherein the controller is removably attached to the passageway and the reservoir. ### Claim 33 (depends on 30) The device of claim 30, wherein the controller is capable of communicating with one or more electronic devices. ### Claim 34 (depends on 19) The device of claim 19, wherein the liquid formulation comprises a flavoring. ### Claim 35 A method of administering a condensation aerosol to a deep lung of a subject, the method comprising: a. generating a condensation aerosol, wherein the generating comprises vaporizing a liquid formulation delivered onto a heater element, wherein the heater element is located in a passageway of a condensation aerosol generating device, wherein the condensation aerosol has an MMAD of from about 1 μm to about 5 μm; and b. flowing a gas through the condensation aerosol generating device to deliver the condensation aerosol to a deep lung of a subject using the device. ### Claim 36 (depends on 35) The method of claim 35, wherein the condensation aerosol generating device is configured to produce an internal air resistance of from about 0.08 to about 0.12 sqrt (cm-H2O)/LPM. ### Claim 37 (depends on 35) The method of claim 35, wherein the passageway comprises an upstream opening and a downstream opening, wherein the upstream opening comprises an inlet for the air and the downstream opening serves as an outlet for air. ### Claim 38 (depends on 37) The method of claim 37, wherein the heater element is located within the passageway between the upstream and downstream openings. ### Claim 39 (depends on 37) The method of claim 37, wherein the condensation aerosol generating device further comprises a reservoir located within the passageway between the upstream and downstream openings. ### Claim 40 (depends on 35) The method of claim 35, wherein the condensation aerosol generating device further comprises an air flow regulator located in the passageway. ### Claim 41 (depends on 40) The method of claim 40, wherein the condensation aerosol generating device further comprises a second passageway, wherein the air flow regulator is capable of directing air through the second passageway in response to a pressure drop across the air flow regulator. ### Claim 42 (depends on 41) The method of claim 41, wherein the air flow regulator comprises one or more gas control valves. ### Claim 43 (depends on 37) The method of claim 37, wherein the heater element comprises a wire coil. ### Claim 44 (depends on 37) The method of claim 37, wherein the condensation aerosol generating device further comprises a capillary in fluid communication with the reservoir. ### Claim 45 (depends on 44) The method of claim 44, wherein the capillary is in fluid communication with the heater element. ### Claim 46 (depends on 44) The method of claim 44, wherein the capillary comprises a heatable region. ### Claim 47 (depends on 46) The method of claim 46, wherein the condensation aerosol generating device further comprises a check valve located in the capillary between the heatable region and the reservoir. ### Claim 48 (depends on 35) The method of claim 35, wherein the condensation aerosol generating device further comprises a controller, wherein the controller comprises a non-transitory computer readable medium comprising one or more algorithms, wherein the one or more algorithms regulate dosing or a delivery schedule of the condensation aerosol of the liquid formulation. ### Claim 49 (depends on 48) The method of claim 48, wherein the condensation aerosol generating device further comprises an interface for communicating with the controller. ### Claim 50 (depends on 48) The method of claim 48, wherein the controller is removably attached to the passageway and the reservoir. ### Claim 51 (depends on 48) The method of claim 48, wherein the controller is capable of communicating with one or more electronic devices. ### Claim 52 A condensation aerosol generating device for generating a condensation aerosol of a liquid formulation, the device comprising: a passageway comprising a heater element, an inlet, and an outlet, wherein the heater element is located between the inlet and the outlet of the passageway, wherein the passageway is adapted to produce a condensation aerosol from a liquid formulation delivered onto the heater element, and wherein the device is configured to produce an internal air resistance that is no greater than that of a cigarette. ### Claim 53 (depends on 52) The device of claim 52, wherein the internal air resistance is at most 0.20 sqrt (cm-H2O)/LPM. ### Claim 54 (depends on 52) The device of claim 52, wherein the internal air resistance is from about 0.08 to about 0.12 sqrt (cm-H2O)/LPM. ### Claim 55 (depends on 52) The device of claim 52, further comprising a reservoir in fluid communication with the heater element. ### Claim 56 (depends on 52) The device of claim 52, wherein the device further comprises an air flow regulator located in the passageway. ### Claim 57 (depends on 56) The device of claim 56, further comprising a second passageway, wherein the air flow regulator is capable of directing air through the second passageway in response to a pressure drop across the air flow regulator. ### Claim 58 (depends on 57) The device of claim 57, wherein the air flow regulator comprises one or more gas control valves. ### Claim 59 (depends on 52) The device of claim 52, wherein the heater element comprises a wire coil. ### Claim 60 (depends on 52) The device of claim 52, wherein the device is configured to detect inhalation from a user. ### Claim 61 (depends on 60) The device of claim 60, wherein the device is further configured to produce the condensation aerosol within 1000 milliseconds from the detection of inhalation from the user. ### Claim 62 (depends on 61) The device of claim 61, wherein the condensation aerosol is present in the first third of the volume of air inhaled by the user. ### Claim 63 (depends on 52) The device of claim 52, wherein the liquid formulation comprises nicotine.