Mouse model of retinal degeneration
AssigneesThe Cleveland Clinic Foundation, Case Western Reserve University
InventorsVictor L. Perez, Joe G. Hollyfield, Robert G. Salomon
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Abstract
The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In particular, the invention provides a method of producing a non-human mammal having age-related macular degeneration (AMD). The invention is also directed to non-human animals produced by the methods described herein. Methods of identifying an agent for use in inhibiting one or more pathological characteristics of retinal degeneration and/or AMD is also encompassed by the invention. Also provided is a method of treating AMD in an individual in need thereof comprising, administering to the individual an agent identified herein.
Claims2
A method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration comprising,
- a) administering a composition comprising an oxidatively modified protein to a non-human mammal;
- and
- b) maintaining the non-human mammal under conditions in which one or more pathological characteristics of retinal degeneration develops in the non-human mammal,
- thereby producing a non-human mammal having one or more pathological characteristics of retinal degeneration.
-24. (canceled)
Dependencies are inferred from the claim text.