Animal models and therapeutic molecules
AssigneeKymab Limited
InventorsAllan Bradley, E-Chiang Lee, Qi Liang, Wei Wang, Anais Legent, Ian Kirby
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Abstract
The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
Claims1
A host rodent whose genome comprises a chimeric immunoglobulin (Ig) locus, said chimeric Ig locus comprising human Ig locus DNA and host Ig locus DNA, said host Ig locus DNA comprising a host Ig upstream region and a host Ig downstream region,
- said host Ig upstream region comprising a host J region comprising a host J segment and said host Ig downstream region comprising a host Ig constant (C) region segment DNA comprising a host C segment,
- wherein said human Ig locus DNA is positioned downstream of said host Ig J region and upstream of said host Ig C region, said human Ig locus DNA comprising one 10 or more human Ig variable (V) segments and one or more human Ig joining (J) segments.
Dependencies are inferred from the claim text.