Composition, device and method for delayed and sustained release of brain energy molecules
AssigneeAble Cerebral, LLC
InventorJun Xia
Life of this patent
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Abstract
The present invention relates to compositions, devices and methods of delayed and sustained release of energy molecules for brain function to treat nocturnal hypoglycemia. The composition comprises an energy molecule required for human brain function; wherein the release of the energy molecule is delayed and then sustained over a period of time. The device is a transdermal delivery device comprising a reservoir layer containing the composition and a skin permeation enhancer formulation, an adhesive layer, a backing layer and a release liner. The method comprises administering the composition either orally or through the transdermal delivery device to a subject in need thereof immediately prior to going to sleep.
Claims22
A delayed and sustained release composition comprising an energy molecule required for human brain function;
- wherein less than 15% by weight of the energy molecule is released within 2 hours after administration, the energy molecule being released at a sustained rate after 2 hours, wherein less than 60% of the energy molecule is released within the first 4 hours and at least 80% of the energy molecule is released within 8 hours after administration.
A transdermal delivery device comprising:
- a reservoir layer comprising absorbent materials inert to chemicals, the reservoir layer containing a composition comprising an energy molecule required for human brain function and a skin permeation enhancer formulation;
- an adhesive layer attached to the reservoir layer and configured to secure the device to the skin and seal it so as to prevent leaking;
- a backing layer coated by the adhesive layer and impermeable by the an energy molecule;
- and
- a release liner that is inert to chemicals;
- and
- the device is configured to release the composition contained in the reservoir layer such that less than 10% by weight of the energy molecule is released within 2 hours after administration, the energy molecule being released at a sustained rate after 2 hours for a period of time up to 8 hours.
Dependencies are inferred from the claim text.