Integrated insulin delivery system having safety features to prevent hypoglycemia

A system for the delivery of insulin to a patient, the system comprising:

• a continuous glucose sensor configured to provide a glucose level signal representative of sensed glucose;
• an insulin delivery device configured to deliver insulin in response to delivery control signals at a basal rate and as a bolus;
• and
• a controller programmed to receive the sensor glucose level signal and to provide a delivery control signal to an insulin delivery device to suspend a basal delivery rate during the provision of a bolus delivery and to automatically resume a preprogrammed basal delivery rate after a selected event.

A system for the delivery of insulin to a patient, the system comprising:

• a continuous glucose sensor configured to provide a glucose level signal representative of sensed glucose;
• an insulin delivery device configured to deliver insulin in response to delivery control signals at a basal rate and as a bolus;
• and
• a controller programmed to receive the sensor glucose level signal and to provide a delivery control signal to the insulin delivery device according to a model, the model including a monitor on the lower level of insulin over the course of time such that if the delivery control signal reduces the insulin delivery below a threshold or terminates insulin delivery, the processor model programming of the processor results in an intervention in the delivery of insulin by the pump to avoid hypoglycemia.

A system for the delivery of insulin to a patient, the system comprising:

• a continuous glucose sensor configured to provide a glucose level signal representative of sensed glucose;
• an insulin delivery device configured to deliver insulin to a patient in response to delivery control signals at a basal rate and as a bolus;
• and
• a controller programmed to receive the sensor glucose level signal and to provide a delivery control signal to the insulin delivery device to deliver insulin in a manner that accounts for an asymmetrical bias range of the glucose sensor such that inaccuracy in the sensor may be tolerated with limited hyperglycemia while avoiding hypoglycemia.

A system for the delivery of insulin to a patient, the system comprising:

• a continuous glucose monitor configured to provide a glucose level signal representative of sensed glucose;
• an insulin delivery device configured to deliver insulin to a patient in response to delivery control signals;
• and
• a controller programmed to provide control signals to the delivery device to result in a basal rate of delivery and bolus delivery, the controller also programmed to receive the glucose level signal and to indicate recommended changes to the delivery of insulin and/or alter the delivery of insulin as a function of the glucose level signals.