Process for the preparation of olmesartan medoxomil
AssigneeLupin Limited
InventorsRajendra Vishwanath Firke, Ujjwal Komalsing Sisodia, Chandrakant Shriram Bhangale, Radhakrishna Bhikaji Shivdavkar, Himanshu Madhav Godbole, Girij Pal Singh
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Abstract
The present invention provides novel process for preparation of olmesartan medoxomil (I) substantially free of olmesartan acid impurity (II) comprising, reacting trityl olmesartan medoxomil (III) with acid, filtering the precipitate of trityl alcohol, subjecting the filtrate to agitated thin film drying and recovering olmesartan medoxomil (I).
Claims15
A process for preparation of olmesartan medoxomil (I) comprising:
- a) reacting trityl olmesartan medoxomil (III) with an acid,
- b) filtering the precipitate of trityl alcohol,
- c) subjecting the filtrate to agitated thin film drying, and
- d) recovering olmesartan medoxomil (I).
A process for preparation of olmesartan medoxomil (I) substantially free of olmesartan acid impurity (II) comprising:
- a) reacting trityl olmesartan medoxomil (III) with an acid,
- b) filtering the precipitate of trityl alcohol,
- c) subjecting the filtrate to agitated thin film drying,
- d) recovering olmesartan medoxomil (I), and
- e) optionally crystallizing olmesartan medoxomil (I) from an organic solvent.
Dependencies are inferred from the claim text.