Chemical compounds

A compound of formula (I):

• Y is a single bond, C═O, C═S or S(O)m where m is 0, 1 or 2;
• the ring
• is a 6 membered aromatic ring or is a 5 or 6 membered heteroaromatic ring;
• Z and Z′ are joined by a single or a double bond and are each independently ═C— or —N— provided that both are not N;
• R1 is hydrogen, optionally substituted alkyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, aminocarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocyclyloxy, cyano, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, formyl, optionally substituted heterocyclyl, optionally substituted alkylthio, NO or NR13R14;
• R13 and R14 are each independently hydrogen, COR15, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl or R13 and R14 together with the N atom to which they are attached form a group —N═C(R16)—NR17R18 or R13 and R14 together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from O, N or S and which may be optionally substituted by one or two C1-6 alkyl groups;
• R15 is H, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted aryloxy optionally substituted heteroaryl, optionally substituted heteroaryloxy or NR19R20;
• R16, R17 and R18 are each independently H or lower alkyl;
• R19 and R20 are independently optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl;
• R2 is H, hydroxy, optionally substituted alkoxy or optionally substituted alkyl;
• or R1 and R2 together with the groups Y and N form a 5- or 6-membered heterocyclic ring which may optionally contain one further heteroatom selected from O, N or S and which may be optionally substituted by C1-4 alkyl, C1-4 haloalkyl or halogen;
• R3 is H, OH, halogen or optionally substituted alkyl;
• R3a is H or R3 and R3a together form a bond;
• two adjacent groups R4 together with the atoms to which they are attached form a 4, 5, 6, or 7 membered carbocyclic, heteroaromatic, or heterocyclic ring optionally carrying one, two or three R5 groups;
• provided that when the two adjacent R4 groups are both attached to carbon atoms to form a carbocyclic or heterocyclic ring then the resulting carbocyclic or heterocyclic ring is substituted with a substituent other than halogen, C1-8 alkoxy, C1-6 haloalkoxy, phenoxy (optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), heteroaryloxy (optionally substituted by halo, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy), C1-8 alkylthio or R19R20N;
• R19 and R20 are each independently hydrogen, C1-8 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, C3-6 alkynyl, C2-6 haloalkyl, or C1-6 alkoxycarbonyl or R19 and R20 together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from O, N or S and which may be optionally substituted by one or two C1-6 alkyl groups;
• optionally any further R4 groups are each independently halogen, nitro, cyano, thiocyanato, optionally substituted C1-8 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted C3-7 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted alkylthio, arylthio, heteroarylthio, alkylsulfoxyl, arylsulfoxyl, heteroarylsulfoxyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl or R23R24N;
• R23 and R24 are each independently hydrogen, C1-8 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, C3-6 alkynyl, C3-7 cycloalkyl(C1-4)alkyl, C2-6 haloalkyl, C1-6 alkoxy(C1-6)alkyl, C1-6 alkoxycarbonyl or R23 and R24 together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from O, N or S and which may be optionally substituted by one or two C1-6 alkyl groups;
• n is 2, 3 or 4;
• each R5 is independently halogen, nitro, cyano, thiocyanato, optionally substituted C1-8 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted C3-7 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted alkylthio, arylthio, heteroarylthio, alkylsulfoxyl, arylsulfoxyl, heteroarylsulfoxyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl or R25R26N;
• R25 and R26 are each independently hydrogen, C1-8 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, C3-6 alkynyl, C3-7 cycloalkyl(C1-4)alkyl, C2-6 haloalkyl, C1-6 alkoxy(C1-6)alkyl, C1-6 alkoxycarbonyl or R25 and R26 together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from O, N or S and which may be optionally substituted by one or two C1-6 alkyl groups;
• R8 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl or optionally substituted alkenylcarbonyl;
• each Ra is independently halogen, hydroxy, cyano, optionally substituted C1-8 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted alkylaminocarbonyl, optionally substituted dialkylaminocarbonyl, optionally substituted C3-7 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted alkylthio, optionally substituted arylthio or R29R30N;
• R29 and R30 are each independently hydrogen, C1-8 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, C3-6 alkenyl, C3-7 cycloalkyl(C1-4alkyl, C2-6 haloalkyl, C1-6 alkoxy(C1-6)alkyl, or C1-6 alkoxycarbonyl;
• or R29 and R30 together with the N atom to which they are attached form a five, six or seven-membered heterocyclic ring which may contain one or two further heteroatoms selected from O, N or S and which may be optionally substituted by one or two C1-6 alkyl groups;
• or two Ra groups attached to the same carbon atom are ═O, ═S, ═NRb, ═CRcRd;
• Rb, Rc and Rd are each independently H or optionally substituted alkyl;
• and
• p is 0, 1, 2, 3 or 4;
• or salts or N-oxides thereof.