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US 2014/0179914 A1Published application
Process for the preparation of 6-alpha-fluoro pregnanes
AssigneeTrifarma S.p.A.
InventorsSimona GRASSI, Stefano Mascheroni, Roberto Giani
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Abstract
Disclosed is a process for the preparation of 6-α-fluoro pregnanes of formula I wherein R1 is an acyl group, R2 can be H, alpha methyl or beta methyl, and the dotted line can represent a double bond, comprising fluorination with electrophilic fluorinating agents in the 6 position of compounds of formula III, wherein R1, R2 and the dotted line have the meanings stated above, in an inert solvent, in the presence of a basic catalyst at temperatures ranging between 0 and 30° C.
Claims9
Process for the preparation of 6-α-fluoro pregnanes of formula I
- wherein R1 is an acyl group, R2 can be H, alpha methyl or beta methyl and the dotted line can represent a double bond, comprising fluorination with electrophilic fluorinating agents at the 6 position of compounds of formula III,
- wherein R1, R2 and the dotted line have the meanings given above, in an inert solvent, in the presence of a basic catalyst and at temperatures ranging from 0 to 30° C.
Dependencies are inferred from the claim text.