Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
AssigneeMolecular Insight Pharmaceuticals, Inc.
InventorsJohn W. BABICH, Craig Zimmerman, John Joyal, Kevin P. Maresca, John Marquis, Genliang Lu, Jian-cheng Wang, Shawn Hillier
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Abstract
Complexes of heterocyclic radionuclides are prepared based upon ligands having substituted pyridyl and imidazolyl groups. The ligands are bifunctional, having amino acid residues that may act as a linker to a bioactive molecule, and a tridentate chelator that may complex the radionuclide. The bioactive molecule may be a peptide or somatostatin.
Claims26
A compound represented by:
- a pharmaceutically acceptable salt thereof;
- f is an integer from 0 to 12;
- and
- g is an integer from 0 to 12.
A method of preparing a peptide conjugate incorporating a compound, the method comprising synthesizing the peptide conjugate using solid-phase peptide-synthesis techniques;
- wherein:
- the compound is:
- a pharmaceutically acceptable salt thereof;
- f is an integer from 0 to 12;
- and
- g is an integer from 0 to 12.
Dependencies are inferred from the claim text.