Double-acylated glp-1 derivatives

A derivative of a GLP-1 analogue,

• which analogue comprises a first K residue at a position corresponding to position 37 of GLP-1(7-37) (SEQ ID NO:
• 1), a second K residue at a position corresponding to position 26 of GLP-1(7-37), and a maximum of ten amino acid modifications as compared to GLP-1(7-37), wherein the first K residue is designated K37, and the second K residue is designated K26,
• which derivative comprises two albumin binding moieties attached to K26 and K37, respectively, wherein
• the albumin binding moiety comprises a protracting moiety selected from Chem. 1, Chem. 2, Chem. 3, and Chem. 4:
• HOOC—(CH2)x—CO—* Chem. 1:
• HOOC—C6H4—O—(CH2)y—CO—* Chem. 2:
• R1—C6H4—(CH2)z—CO—* Chem. 3:
• HOOC—C4SH2—(CH2)w—CO—* Chem. 4:
• in which x is an integer in the range of 6-18, y is an integer in the range of 3-17, z is an integer in the range of 1-5, R1 is a group having a molar mass not higher than 150 Da, and w is an integer in the range of 6-18;
• with the proviso that when the protracting moiety is Chem. 1, the albumin binding moiety further comprises a linker of formula Chem. 5:
• wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5;
• or a pharmaceutically acceptable salt, amide, or ester thereof.