Methods Of Manufacturing Contact Lenses For Delivery Of Beneficial Agents

A method of manufacturing a contact lens, said method comprising:

• a) polymerizing a monomer mixture comprising at least one carboxylic-acid containing monomer to form a lens-shaped polymerization product comprising carboxylic acid groups;
• b) placing the lens-shaped polymerization product in a package containing a packaging solution comprising a buffer and a beneficial cationic agent, wherein said packaging solution has an osmolality of about 200 to about 400 mOsm/kg, and wherein said packaging solution i) has an ionic strength of less than about 0.1, or ii) is temperature-sensitive, or iii) has an ionic strength of less than about 0.1 and is temperature-sensitive;
• and
• c) sealing and autoclaving the package to provide a sterile packaged contact lens, wherein the beneficial cationic agent ionically binds to the carboxylic acid groups and releases from the contact lens in an in vitro release assay.