Back to results
US 2014/0179808 A1Published application
Detection of Ovarian Carcinoma by Assay for Autoantibodies to Multiple Antigens
AssigneeBio-Rad Laboratories, Inc.
InventorJohn J. Flanagan
Life of this patent
Estimating the term…
Abstract
Assays and reagents for the detection of autoantibodies to detect ovarian carcinomas are provided.
Claims23
A method of determining the amount of autoantibodies to insulin-like growth factor binding protein 2 (IGF2BP2), HMGA2, MYCN, and TGIF2LX in a blood sample from a human patient that is being evaluated for ovarian cancer, the method comprising,
- contacting a blood sample obtained from the patient with one or more peptides of 10 amino acids or greater in length from each of the antigens IGF2BP2, HMGA2, MYCN, and TGIF2LX;
- and
- measuring the amount of selective binding of autoantibodies to the one or more peptides.
A kit for detecting ovarian cancer in a human patient, wherein the kit comprises the following components:
- one or more IGF2BP2 peptides that specifically detect an autoantibody to IGF2BP2;
- one or more HMGA2 peptides that specifically detect an autoantibody to HMGA2;
- one or more TGIF2LX peptides that specifically detect an autoantibody to TGIF2LX;
- and
- one or more MYCN peptides that specifically detect an autoantibody to MYCN.
2 more elements
Dependencies are inferred from the claim text.