Deuterium Substituted Fumarate Derivatives
OwnerJianhua CHAOinventor
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Abstract
Provided is a compound of formula (I): or a pharmaceutically acceptable salt thereof. Also provided is a method of activating the Nrf2 pathway, comprising contacting cells with a sufficient amount of a compound of formula (I) described herein. Also provided is a method of treating a neurodegenerative disease, comprising administering to a subject in need of treatment for the neurodegenerative disease an effective amount of a compound of formula (I) described herein.
Claims14
A compound of formula (I)
- or a pharmaceutically acceptable salt thereof, wherein
- each of R1 and R2, independently, is hydrogen, deuterium, deuterated methyl, deuterated ethyl, C1-6 aliphatic, phenyl, 3-7 membered saturated or partially unsaturated monocyclic carbocyclic ring, 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and
- each of R3 and R4, independently, is hydrogen or deuterium, provided that the compound of formula (I) contains at least one deuterium atom and that R1 and R2 are not hydrogen at the same time.
A compound of formula (I) wherein the compound is (2H6)dimethyl fumaric acid ester, (2H3)methyl fumaric acid ester, (2H3)dimethyl fumaric acid ester, or dimethyl fumaric(2,3-2H2) acid ester.
Dependencies are inferred from the claim text.