Methods for inhibition of shc-1/p66 to combat aging-related diseases
AssigneeIndustrial Technology Research Institute
InventorsShau-Feng CHANG, Chun-Hsien MA, Kuo-Yi YANG
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Abstract
The present invention relates to methods of treating one or more symptoms of a SHC-1/p66-related disease, inhibiting ROS generation or for the manufacture of a medicament in the above-mentioned treatment.
Claims17
A method of treating one or more symptoms of a SHC-1/p66-related disease selected from the group consisting of aging, diabetes, and reperfusion injuries after ischemia comprising administering a polymeric composition comprising monomer units having formula I and/or a pharmaceutically acceptable salt, solvate, or prodrug thereof:
- to a mammal in need thereof,
- wherein in Formula I, each of R1 and R2, independently, is H, alkyl, or acyl;
- each of R3, R4, R5, R6, and R7, independently, is H, OH, alkoxyl, or acyl;
- and R8 is H or a saccharide moiety;
- and wherein the polymerized number of the monomer ranges from 2-30, and the average molecular weight of the polymer ranges from 600-10,000.
A method of inhibiting hepatocyte swelling comprising administering a polymeric composition comprising monomer units having formula I and/or a pharmaceutically acceptable salt, solvate or prodrug thereof:
- to a mammal in need thereof,
- wherein in Formula I, each of R1 and R2, independently, is H, alkyl, or acyl;
- each of R3, R4, R5, R6, and R7, independently, is H, OH, alkoxyl, or acyl;
- and R8 is H or a saccharide moiety;
- and wherein the polymerized number of the monomer ranges from 2-30, and the average molecular weight of the polymer ranges from 600-10,000.
A method of reducing the production of reactive oxygen species (ROS) comprising administering a polymeric composition comprising monomer units having formula I and/or a pharmaceutically acceptable salt, solvate or prodrug thereof:
- to a mammal in need thereof,
- wherein in Formula I, each of R1 and R2, independently, is H, alkyl, or acyl;
- each of R3, R4, R5, R6, and R7, independently, is H, OH, alkoxyl, or acyl;
- and R8 is H or a saccharide moiety;
- and wherein the polymerized number of the monomer ranges from 2-30, and the average molecular weight of the polymer ranges from 600-10,000.
A polymeric composition comprising monomer units having formula I
- wherein in Formula I, each of R1 and R2, independently, is H, alkyl, or acyl;
- each of R3, R4, R5, R6, and R7, independently, is H, OH, alkoxyl, or acyl;
- and R8 is H or a saccharide moiety;
- and wherein the polymerized number of the monomer ranges from 2-30, in the form of a nutrient, nutriceutical, health food, or supplement.
Dependencies are inferred from the claim text.