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US 2014/0179754 A1Published application
Fused tricyclic ether carbamates and their use
AssigneesNational University Corporation Kumamoto University, Purdue Research Foundation
InventorsArun K. GHOSH, Chun-Xiao Xu, Hiroaki Mitsuya, Garth Parham
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Abstract
Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds for treating patients infected with HIV are also described.
Claims21
A compound selected from the group consisting of compounds of the formulas
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof, wherein
- X1 is a bond and R6 is hydrogen;
- X2 is S(O)2, and R4 is optionally substituted aryl;
- R1 and R2 are each hydrogen;
- R3 is alkyl, which is optionally substituted;
- R5 is optionally substituted arylalkyl;
- Z is
- wherein * indicates the point of attachment;
- n is 1 or 2;
- W1 and W2 are in each instance independently selected from the group consisting of optionally substituted methylene, oxygen, and amino;
- W3 and W4 are in each instance independently selected from the group consisting of amino, oxygen, alkylene, and heteroalkylene, wherein at least one of W1 or W2 is oxygen, and wherein when one of W1 or W2 is optionally substituted methylene, at least one of W3 or W4 is oxygen, and wherein Z does not include a peroxide bond, a sulfenate bond, or a sulfenamide bond;
- X3 is a bond;
- and
- Y is hydrogen.
11 more elements
12-28. (canceled)
(canceled)
A method for treating a patient in need of relief from an HIV infection, the method comprising the step of administering to a patient in need of relief from
Dependencies are inferred from the claim text.