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AssigneesMassachusetts Institute of Technology, Children's Medical Center Corporation
InventorsLarry I. Benowitz, Stephen J. Lippard, Paul Rosenberg, Yiqing Li, Zhen Huang
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Disclosed herein are methods to promote axonal outgrowth of a neuron comprising, contacting the neuron with an effective amount of a chelating agent, to thereby promote axonal outgrowth in the neuron. Also disclosed are methods of treating a subject for a CNS lesion, comprising, administering to the subject a therapeutically effective amount of a chelating agent, Also disclosed are devices for promoting regeneration in a lesioned neuron, and pharmaceutical compositions comprising a therapeutically effective amount of a chelating agent formulated for localized administration directly to an injured neuron. Examples of such chelating agents are provided.
A method of promoting axonal outgrowth of a neuron comprising contacting the neuron with an effective amount of a chelating agent, to thereby promote axonal outgrowth in the neuron.
A method of treating a subject for a CNS lesion, comprising, administering to the subject a therapeutically effective amount of a chelating agent, wherein administering results in contacting one or more lesioned CNS neurons of the subject with the chelating agent, to thereby promote regeneration in the CNS neurons.
Dependencies are inferred from the claim text.