N-Substituted-Heterocycloalkyloxybenzamide Compounds and Methods of Use

A compound having the structural formula

• or a pharmaceutically acceptable salt or N-oxide thereof, wherein
• each R3 is independently selected from halo, cyano, —(C1-C4 fluoroalkyl), —O—(C1-C4 fluoroalkyl), acyl, carboxylate, carboxamide and nitro;
• w is 0, 1, 2 or 3;
• each R4 is independently selected from —(C1-C6 alkyl), —(C1-C6 fluoroalkyl), -halogen, —NO2 and —CN, and two R4 on the same carbon optionally combine to form oxo;
• x is 0, 1, 2, 3 or 4;
• each R5 is independently selected from —(C1-C6 alkyl), —(C1-C6 fluoroalkyl), —(C0-C6 alkyl)-L-R7, —(C0-C6 alkyl)-NR8R9, —(C0-C6 alkyl)-OR10, —(C0-C6 alkyl)-S(O)0-2R10, -halogen, —NO2 and —CN;
• y is 0, 1, 2, 3 or 4;
• G is a single bond, —CH2— or —C(O)—;
• v is 0, 1, 2, 3 or 4;
• each R15 is independently selected from —(C1-C6 alkyl), —(C1-C6 fluoroalkyl), -halogen, —NO2 and —CN, and two R15 on the same carbon optionally combine to form oxo;
• and
• R17 is optionally-substituted aryl;
• in which
• each L is independently selected
• from —NR9C(O)O—, —NR9C(O)—NR9—, —NR9C(O)S—, —NR9C(O)—, —NR9C(S)O—, —NR9C(S)—NR9—, —NR9C(S)S—, —NR9C(S)—, —OC(O)NR9—, —SC(O)NR9—, —C(S)NR9—, —OC(S)NR9—, —SC(S)NR9—, —C(S)NR9—, —S(O)0-2—, —C(O)O, —OC(O)—, —C(S)O—, —OC(S)—, —C(O)S—, —SC(O)—, —C(S)S—, —SC(S)—, —OC(O)O—, —SC(O)O—, —OC(O)S—, —SC(S)O—, —OC(S)S—, —NR9C(NR9)NR9—, —NR9SO2—, —SO2NR9— and —NR9SO2NR9—,
• each R7, R8 and R1° is independently selected from H, —(C1-C6 alkyl), —(C1-C6 fluoroalkyl), —(C0-C6 alkyl)-L-(C0-C6 alkyl), —(C0-C6 alkyl)-NR9(C0-C6 alkyl), —(C0-C6 alkyl)-O—(C0-C6 alkyl) and —(C0-C6 alkyl)-S(O)0-2—(C0-C6 alkyl),
• each R9 is independently selected from —H, —(C1-C4 alkyl) and —C(O)—(C1-C4 alkyl), and
• each R16 is independently selected from —(C1-C6 alkyl), —(C1-C6 fluoroalkyl), and two R16 on the same carbon optionally combine to form oxo;
• provided that the compound is not
• N-(1-benzylpiperidin-4-yl)-3-chloro-4-(1-(4-methoxybenzyl)piperidin-4-yloxy)benzamide;
• N-(1-benzylpiperidin-4-yl)-4-(1-benzylpiperidin-4-yloxy)-3-methoxybenzamide;
• or
• N-(1-benzylpiperidin-4-yl)-3-(1-benzylpiperidin-4-yloxy)benzamide.