TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF ENZYMESp INVOLVED IN THE PATHOLOGY OF MYCOBACTERIUM TUBERCULOSIS

A compound of Formula A, or a pharmaceutically acceptable salt thereof,

• wherein X is O or NR2;
• R1 is selected from the group consisting of:
• and hydrogen and each occurrence of R2 can be the same or different and is H or C1-C6 alkyl;
• each occurrence of R3 can be the same or different and is H, halogen, hydroxyl, NR2R2, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkenyl, substituted or unsubstituted C1-C6 alkynyl, O-(substituted or unsubstituted C1-C6 alkyl), S-(substituted or unsubstituted C1-C6 alkyl), O-(substituted or unsubstituted aryl), O-(substituted or unsubstituted heteroaryl), S-(substituted or unsubstituted aryl), S-(substituted or unsubstituted heteroaryl), substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, cyano, SO2-(substituted or unsubstituted C1-C6 alkyl), SO2NR2R2, C(O)-(substituted or unsubstituted C1-C6 alkyl), C(O)-(substituted or unsubstituted aryl), C(O)-(substituted or unsubstituted heteroaryl), (CH2)nCO2H, or O(CH2)nCO2H;
• Y is H, halogen, hydroxyl, NR2R2, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkenyl, substituted or unsubstituted C1-C6 alkynyl, O-(substituted or unsubstituted C1-C6 alkyl), S-(substituted or unsubstituted C1-C6 alkyl), O-(substituted or unsubstituted aryl), O-(substituted or unsubstituted heteroaryl), S-(substituted or unsubstituted aryl), S-(substituted or unsubstituted heteroaryl), substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, cyano, SO2C1-C6 alkyl, SO2NR2R2, C(O)-(substituted or unsubstituted C1-C6 alkyl), C(O)-(substituted or unsubstituted aryl), C(O)-(substituted or unsubstituted heteroaryl);
• —(CH2)nCOZ, or —O—(CH2)n-COZ;
• n can be the same or different at each occurrence and is 1, 2, 3, or 4;
• Z is —OH, or N(R4)2, wherein each occurrence of R4 can be the same or different and is H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C1-C6 alkenyl, substituted C1-C6 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, OR5, NHR5,
• and
• R5 is substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C(O)-(substituted or unsubstituted C1-C6alkyl), C(O)-(substituted or unsubstituted aryl), C(O)-(substituted or unsubstituted heteroaryl), or C(O)-(substituted or unsubstituted C3-C8 cycloalkyl).

A compound of Formula C, or a pharmaceutically acceptable salt thereof,

• wherein D is O or NR8;
• R8 is H or C1-C6 alkyl;
• E is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted C3-C8 cycloalkyl;
• and
• G is C(O)-(substituted or unsubstituted C1-C6 alkyl), C(O)-(substituted or unsubstituted C3-C8 cycloalkyl), C(O)-(substituted or unsubstituted C1-C6 alkenyl), C(O)-(substituted or unsubstituted C1-C6 alkynyl), C(O)-(substituted or unsubstituted aryl), or C(O)-(substituted or unsubstituted heteroaryl)