Solid pharmaceutical dosage form
OwnerJoerg Rosenberg, Ulrich Reinhold +5inventors
InventorsJoerg Rosenberg, Ulrich Reinhold, Bernd Liepold, Gunther Berndl, Joerg Breitenbach, Laman Alani, Soumojeet Ghosh
Life of this patent
Estimating the term…
Abstract
A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 5° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
Claims25
A solid pharmaceutical dosage form comprising a solid dispersion, wherein said solid dispersion comprises
- at least one HIV protease inhibitor, wherein said at least one HIV protease inhibitor comprises ritonavir;
- at least one pharmaceutically acceptable surfactant having an HLB value of from about 4 to about 10 or a combination of pharmaceutically acceptable surfactants having an HLB value of from about 4 to about 10;
- and
- at least one pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. or a combination of pharmaceutically acceptable water-soluble polymers having a Tg of at least about 50° C.
Dependencies are inferred from the claim text.