Heteroaryl compounds and uses thereof

A composition comprising a compound of Formula VI:

• or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients, wherein:
• X and X′ are each independently O;
• p and q are each independently 0 or 1, wherein p and q are not both 1;
• R1 is —OR′, —OCH2CH2OR′ or —OCH2CO2H;
• R′ is —H or —CH3;
• each Glu is a glucuronyl moiety;
• A is selected from —H or
• R2 and R3 are each independently —H, —OH, —OSO3H, —OGlu, or:
• R2 and R3 are taken together to form a double bond;
• or:
• R2 and R3 are taken together with their intervening atoms to form an epoxide moiety;
• R2′ is —H, or:
• R2 and R2′ are taken together to form ═O;
• R3′ and R3″ are each —H, or:
• R3′ and R3″ are taken together to form ═O;
• R4 is —H, —OH, —OSO3H or —OGlu;
• Rx and Ry are each independently —OH, —OSO3H, or —OGlu;
• Rz, Rz′ and Rz″ are each independently —H, —CH3, —OH, —OSO3H, or —OGlu;
• or
• Rz″ and R3 are taken together to form —O—;
• m and n are each independently 0, 1, 2, 3 or 4,
• provided that when R2 and R3 are taken together to form a double bond, at least one of the following is true:
• (a) R1 is —OH, —OSO3H, —OGlu, —OCH2CH2OH, —OCH2CO2H, —OCH2CH2OSO3H or —OCH2CH2OGlu;
• (b) at least one of R4, Rx, Ry, Rz, Rz′ and Rz″ is —OH, —OSO3H or —OGlu;
• or
• (c) one of p or q is 1.