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US 2014/0179711 A1Published application
Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
AssigneeBristol-Myers Squibb Company
InventorsJean Lajeunesse, John D. DiMarco, Michael Galella, Ramakrishnan Chidambaram
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Abstract
The invention relates to processes for preparing compounds having the formula, and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R2, R3, R4, and R5, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.
Claims2
A pharmaceutical composition comprising,
- a therapeutically acceptable amount of crystalline monohydrate of the compound of formula (IV)
- and pharmaceutically acceptable carriers, including three or more of, a binder, a diluent, a disintegrant, and/or a lubricant.
Dependencies are inferred from the claim text.