Antiviral salts
AssigneeBiota Scientific Management Pty Ltd.
InventorsJane Ryan, Margaret Anne Butt
Life of this patent
Estimating the term…
Abstract
This invention relates to antiviral agents, in particular to salts useful in the treatment of infections caused by Picornaviridae, such as human rhinovirus (HRV) and methods for their preparation. The invention also relates to the use of these salts in the treatment of picornavirus infections. The salts of this invention are especially suitable for use in the treatment of HRV, however it is to be understood that the invention is also applicable to other viruses of the picornavirus family.
Claims18
1-21. (canceled)
A method of treating a picornavirus infection in a subject in need thereof, comprising the step of administering to the subject an effective amount of a crystalline form of 6-{2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxyl-3-ethoxy-1,2-benzisoxazole bis-dihydrogenphosphate salt (1:2), wherein the crystalline form has an X-Ray Powder Diffraction pattern with 20 peaks (±0.2°) at 3.3°, 6.7°, 12.8°, 13.3°, 14.1°, 19.2°, 20.0°, 21.1° and 22.4°.
A method of preventing a picornavirus infection in a subject in need thereof, comprising the step of administering to the subject an effective amount of a crystalline form of 6-{2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy}-3-ethoxy-1,2-benzisoxazole bis-dihydrogenphosphate salt (1:2), wherein the crystalline form has an X-Ray Powder Diffraction pattern with 20 peaks (±0.2°) at 3.3°, 6.7°, 12.8°, 13.3°, 14.1°, 19.2°, 20.0°, 21.1° and 22.4°.
Dependencies are inferred from the claim text.