Methods of treating hemoglobinopathies
AssigneeDuke Univeristy
InventorRahima Zennadi
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Abstract
Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin H disease are provided. In some embodiments, the methods comprise administering an inhibitor selected from an ERK inhibitor, a MEK inhibitor, and a Raf inhibitor. Methods of inhibiting adhesion of sickle red blood cells to endothelial cells are also provided.
Claims33
A method of alleviating at least one symptom of a hemoglobinopathy in a patient comprising administering an inhibitor selected from a MEK inhibitor, an ERK inhibitor, and a Raf inhibitor.
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A method of inhibiting adhesion of cells comprising contacting sickle red blood cells with an inhibitor selected from a MEK inhibitor, an ERK inhibitor, and a Raf inhibitor.
A method of alleviating at least one of acute pain, chronic hemolysis (aplastic crises), avascular necrosis, organ damage, and erythroid hyperplasia comprising contacting the sickle red blood cells with an inhibitor selected from a MEK inhibitor, an ERK inhibitor, and a Raf inhibitor.
Dependencies are inferred from the claim text.