US 2014/0179695 A1 · CHROMANE COMPOUNDS

Abstract

The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by β-secretase activity, hydrolysis of a β-secretase site of a β-amyloid precursor protein, and/or β-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.

Claims22

Dependent claims

A compound of the formula (I) or a salt thereof:

wherein
A1 is O;
A2 is —C(RA21RA22)—;
and
RA21 and RA22 are H;
B is
an oxygen-containing monocyclic saturated hetero ring group or
cycloalkyl, wherein said cycloalkyl is unsubstituted or substituted with halogen;
X is lower alkyl;
Y is lower alkyl;
R1 and R4 are H;
R3 is H or halogen;
and
R2 is —N(H)—C(O)-(hetero ring group), wherein said hetero ring group is unsubstituted or substituted with one or more substituents selected from the group consisting of
halogen,
lower alkyl which is unsubstituted or substituted with halogen,
—CN, and
—O-(lower alkyl).

15 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/192,667Filed 27 Feb 2014

Priority

30 May 2012

Published

26 Jun 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

C07D 413/14
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms:…
A61P 25/28
Drugs for disorders of the nervous system: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents,…
C07D 263/52
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings: condensed with carbocyclic rings or ring systems
C07D 498/10
In which the condensed system contains two hetero rings: spiro-condensed systems

Chromane compounds

Life of this patent

Chromane compounds

Life of this patent

Abstract

Claims22