PLOD-2 Modulators and Their Use in the Treatment of Skin
AssigneeAvon Products, Inc.
InventorsUma Santhanam, Permanan Raaj Khusial
Life of this patent
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Abstract
Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that modulate the PLOD-2 enzyme in the skin. Also provided are methods for screening for substances which modulate PLOD-2 enzyme levels and the methods of using active agents identified by the screening protocol in the treatment of skin.
Claims19
A cosmetic composition for improving the aesthetic appearance of human skin comprising a cosmetically acceptable vehicle, and an effective amount of an active agent that upregulates PLOD-2 by at least 25%, with the proviso that said active agent is not N-Acetyl-Tyrosinamide.
A method for improving the aesthetic appearance of human skin comprising topically applying to an area of the skin in need thereof an effective amount of an active agent, other than N-Acetyl-Tyrosinamide, that stimulates PLOD-2 expression, wherein said active agent upregulates PLOD-2 by at least 25%, for a time sufficient to improve the aesthetic appearance of said human skin.
A method for improving the aesthetic appearance of human skin comprising topically applying to an area of the skin in need thereof a composition comprising a retinoid and an effective amount of at least one active agent that modulates cellular levels of PLOD-2 other than N-Acetyl-Tyrosinamide.
A method for screening active agents useful for improving the aesthetic appearance of skin comprising assaying candidate substances for ability to stimulate PLOD-2 expression in a dermal fibroblast or keratinocyte.
A method of treating the skin comprising topically applying to an area of the skin in need thereof an effective amount of an active agent that modulates PLOD-2 expression, other than N-Acetyl-Tyrosinamide, wherein the ability of said active agent to modulate PLOD-2 has been determined by an assay which measures PLOD-2 expression in a dermal fibroblast or keratinocyte.
A method for improving the aesthetic appearance of human skin comprising topically applying to an area of the skin in need thereof an effective amount of retinol in combination with an active agent that modulates cellular levels of PLOD-2, other than N-Acetyl-Tyrosinamide, wherein the ability of said active agent to modulate PLOD-2 has been determined by an assay which measures the expression level of PLOD-2 in a cell that has been contacted with said active agent.
Dependencies are inferred from the claim text.