Therapeutic agent for ectopic pregnancy
AssigneeAkita University
InventorKazuhiro Kawamura
Life of this patent
Estimating the term…
Abstract
A novel therapeutic agent for ectopic pregnancy having a therapeutic effect for ectopic pregnancy, especially unruptured ectopic pregnancy, and a novel method of screening a therapeutic agent for ectopic pregnancy are disclosed. The therapeutic agent for ectopic pregnancy contains as an effective ingredient a suppressor of brain-derived neurotrophic factor (BDNF) and/or of brain-derived neurotrophic factor receptor (TrkB). The method of screening a therapeutic agent for ectopic pregnancy includes measuring the kinase activity of TrkB in the presence of a test substance and the kinase activity of TrkB in the absence of the test substance; and selecting the test substance which decreases the kinase activity of TrkB.
Claims11
A therapeutic agent for ectopic pregnancy, comprising as an effective ingredient a suppressor of brain-derived neurotrophic factor (BDNF) and/or of brain-derived neurotrophic factor receptor (TrkB).
A method of screening a therapeutic agent for ectopic pregnancy, said method comprising measuring the kinase activity of TrkB in the presence of a test substance and the kinase activity of TrkB in the absence of said test substance;
- and selecting a test substance which decreases the kinase activity of TrkB.
A method of screening a therapeutic agent for ectopic pregnancy, said method comprising the following steps (a) to (d):
- (a) preparing model animals in which human placental villi are transplanted to a renal tissue of a mammal other than human;
- (b) administering a test sample to one (or one population) of said model animals prepared and raising the animal(s), and administering only the carrier in said test sample to another (or another population) of said model animals prepared and raisin the animal(s);
- (c) comparing cytotrophoblast cells and extravillous trophoblast cells in said renal tissue in said model animal(s) to which said test sample was administered with cytotrophoblast cells and extravillous trophoblast cells in said renal tissue in said model animal(s) to which said test sample was not administered;
- and
- (d) selecting the test sample as a therapeutic agent for ectopic pregnancy, which test sample decreased cytotrophoblast cells and extravillous trophoblast cells in said renal tissue in said model animal(s) to which said test sample was administered.
A suppressor of brain-derived neurotrophic factor (BDNF) and/or of brain-derived neurotrophic factor receptor (TrkB) for use in the treatment of ectopic pregnancy.
A method of treating ectopic pregnancy, said method comprising administering an effective amount of a suppressor of brain-derived neurotrophic factor (BDNF) and/or of brain-derived neurotrophic factor receptor (TrkB) to a patient with ectopic pregnancy.
Dependencies are inferred from the claim text.