Fused pyrimidine compounds and use thereof

A compound of the formula (I):

• or a salt thereof, wherein:
• D is hydrogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted heterocyclyl, or taken together with RD and the nitrogen to which they are attached to form a substituted or unsubstituted heterocyclyl;
• E is substituted or unsubstituted heteroaryl;
• each j, k, m, and n is independently 0 or 1;
• each RA1, RA2, RA3, RA4, RA5, RA6, RA7, RA8, RA9 and RA10, where present, is independently hydrogen, substituted or unsubstituted C1-C6 alkyl, halo, hydroxy, —OR1, —SH, —S(O)pR2, —NR3R4, —C(O)NR5R6, —C(O)OR7, —OC(O)R8, —C(O)R9, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or taken together with a geminal RA(1-10) group and the carbon to which they are attached to form carbonyl, thiocarbonyl, a C3-C6 cycloalkyl, or a heterocyclyl;
• RD is hydrogen, substituted or unsubstituted C1-C6 alkyl, or taken together with D and the nitrogen to which they are attached to form a substituted or unsubstituted heterocyclyl;
• X is O or S;
• RZ is hydrogen, or substituted or unsubstituted C1-C6 alkyl;
• each RZ1 and RZ2 is independently hydrogen, or substituted or unsubstituted C1-C6 alkyl, or RZ1 and RZ2 are taken together with the carbon to which they are attached to form a carbonyl or a C3-C6 cycloalkyl;
• each RZ3, RZ4, RZ5, RZ6, RZ7 and RZ8, where present, is independently hydrogen, substituted or unsubstituted C1-C6 alkyl, halo, hydroxy, —OR1, —O—C1-C6 alkylene-P(O)(OH)2, —SH, —S(O)pR2, —NR3R4, —C(O)NR5R6, —C(O)OR7, —OC(O)R8, —C(O)R9, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or is taken together with a geminal RZ(3-8) group and the carbon to which they are attached to form carbonyl, thiocarbonyl or a C3-C6 cycloalkyl;
• each p is independently 0, 1 or 2;
• each R1 is independently a substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C3-C8 cycloalkyl, or substituted or unsubstituted aryl;
• each R2 is independently a substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted aryl or hydroxyl;
• each R3, R4, R5, R6 and R7 is independently hydrogen, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C3-C8 cycloalkyl;
• and
• each R8 and R9 is independently hydrogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.