Aryl and heteroaryl fused lactams

A compound of formula (II):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• U is N or CR3;
• V is N or CR4;
• R1 is C1-C8 alkyl, C1-C8 alkoxy, halo, —OH, —CN or —NR7R8, where each said C1-C8 alkyl or C1-C8 alkoxy is optionally substituted by one or more R21;
• R2 is selected from the group consisting of H, C1-C8 alkyl, C1-C8 alkoxy, —OR6, —NR7R8, —C(O)NR7R8, —SO2NR7R8, —NR7SO2R8, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl and 5-12 membered heteroaryl, where each said C1-C8 alkyl or C1-C8 alkoxy is optionally substituted by one or more R22, and each said C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl or 5-12 membered heteroaryl is optionally substituted by one or more R32;
• R3 is H, C1-C8 alkyl, C1-C8 alkoxy, halo, —OH, —CN or —NR7R8, where each said C1-C8 alkyl or C1-C8 alkoxy is optionally substituted by one or more R23;
• R4 is selected from the group consisting of H, halo, C1-C8 alkyl, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl, 5-12 membered heteroaryl, —(C1-C4 alkyl)Rz, —ORx, —CN, —C(O)Rx, —CO2Rx, —C(O)NRxRy, —SRx, —SORx, —SO2Rx, —SO2NRxRy, —NO2, —NRxRy, —NRxC(O)Ry, —NRxC(O)NRxRy, —NRxC(O)ORy, NRxSO2Ry, —NRxSO2NRxRy, —OC(O)Rx and —OC(O)NRxRy;
• each Rx and Ry is independently selected from the group consisting of H, C1-C8 alkyl, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl and 5-12 membered heteroaryl;
• or Rx and Ry may be taken together with the N atom to which they are attached to form a 3-12 membered heterocyclyl or 5-12 membered heteroaryl ring, each optionally containing 1, 2 or 3 additional heteroatoms selected from O, N and S;
• each Rz is independently selected from the group consisting of C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl and 5-12 membered heteroaryl;
• and
• wherein each said C1-C8 alkyl in R4, Rx or Ry and each said C1-C4 alkyl in (C1-C4 alkyl)Rz is optionally substituted by one or more R24, and each said C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl, or 5-12 membered heteroaryl in R4, Rx, Ry, Rz, or Rx and Ry taken together is optionally substituted by one or more R34;
• each R5 is independently selected from the group consisting of halo, —OH, ═O, C1-C4 alkyl, C1-C4 alkoxy, —CN, —NR9R10 and —C(O)NR9R10, where each said C1-C4 alkyl or C1-C4 alkoxy is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, —OH, C1-C4 alkoxy, —CN, —NR9R10 and —C(O)NR9R10;
• R6 is —(CR11R12)n—R13;
• each R7 and R8 is independently selected from the group consisting of H, C1-C8 alkyl, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl, and 5-12 membered heteroaryl;
• or
• R7 and R8 may be taken together with the N atom to which they are attached to form a 3-12 membered heterocyclyl or 5-12 membered heteroaryl, each optionally containing 1, 2 or 3 additional heteroatoms selected from O, N and S;
• where each said C1-C8 alkyl in R7 or R8 is optionally substituted by one or more R27, and each said C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl, or 5-12 membered heteroaryl in R7, R8, or R7 and R8 taken together is optionally substituted by one or more R37;
• each R9 and R10 is independently H or C1-C4 alkyl;
• or
• R9 and R10 may be taken together with the N atom to which they are attached to form a 3-12 membered heterocyclyl or 5-12 membered heteroaryl, each optionally containing 1, 2 or 3 additional heteroatoms selected from O, N and S;
• where each said C1-C4 alkyl in R9 or R10, and each said 3-12 membered heterocyclyl or 5-12 membered heteroaryl in R9 and R10 taken together is optionally substituted by 1 to 3 substituents independently selected from the group consisting of halo, —OH, ═O, C1-C4 alkyl, C1-C4 alkoxy, —CN, —NH2, —NH(C1-C4 alkyl) and —N(C1-C4 alkyl)2;
• each R11 and R12 is independently H, halo or C1-C4 alkyl, where each said C1-C4 alkyl is optionally substituted by one or more R22;
• R13 is selected from the group consisting of C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl, and 5-12 membered heteroaryl, where each said C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl or 5-12 membered heteroaryl is optionally substituted by one or more R32;
• m is 0 to 4;
• n is 0 to 4;
• each R21, R22, R23 and R24 is independently selected from the group consisting of halo, C1-C8 alkyl, —CN, ═O, —C(O)Re, —CO2Re, —C(O)NReRf, —ORe, —SRe, —SORe, —SO2Re, —SO2NReRf, —NO2, —NReRf, —NReC(O)Rf, —NReC(O)NReRf, —NReC(O)ORf—NReSO2Rf, —NReSO2NReRf, —OC(O)Re, —OC(O)NReRf, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl and 5-12 membered heteroaryl;
• each Re and Rf is independently selected from the group consisting of H, C1-C8 alkyl, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl and 5-12 membered heteroaryl;
• or
• Re and Rf may be taken together with the N atom to which they are attached to form a 3-12 membered heterocyclyl or 5-12 membered heteroaryl ring, each optionally containing 1, 2 or 3 additional heteroatoms selected from O, N and S;
• wherein each said C1-C8 alkyl, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl or 5-12 membered heteroaryl in R24, Re, Rf, or Re and Rf taken together is optionally substituted by 1 to 3 substituents independently selected from the group consisting of halo, —OH, ═O, C1-C4 alkyl, C1-C4 alkoxy, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C4 alkoxy-C1-C6 alkyl, —CN, —NH2, —NH(C1-C4 alkyl) and —N(C1-C4 alkyl)2;
• each R27 is independently selected from the group consisting of halo, —OH, C1-C4 alkoxy, —CN, —NR9R10, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl and 5-12 membered heteroaryl, where each said C1-C4 alkoxy, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl or 5-12 membered heteroaryl is optionally substituted by 1 to 3 substituents independently selected from the group consisting of halo, —OH, ═O, C1-C4 alkyl, C1-C4 alkoxy, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C4 alkoxy-C1-C6 alkyl, —CN, —NH2, —NH(C1-C4 alkyl) and —N(C1-C4 alkyl)2;
• each R32, R34 and R37 is independently selected from the group consisting of halo, C1-C8 alkyl, —CN, ═O, —C(O)Rc, —CO2Rc, —C(O)NRcRd, —ORc, —SRc, —SORc, —SO2Rc, —SO2NRcRd, —NO2, —NRcRd, —NRcC(O)Rd, —NRcC(O)NRcRd, —NRcC(O)ORd, —NRcSO2Rd, —NRcSO2NRcRd, —OC(O)Rc, —OC(O)NRcRd, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl and 5-12 membered heteroaryl;
• each Rc and Rd is independently selected from the group consisting of H, C1-C8 alkyl, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl and 5-12 membered heteroaryl;
• or
• Rc and Rd may be taken together with the N atom to which they are attached to form a 3-12 membered heterocyclyl or 5-12 membered heteroaryl ring, each optionally containing 1, 2 or 3 additional heteroatoms selected from O, N and S;
• wherein each said C1-C8 alkyl, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl or 5-12 membered heteroaryl in R32, R34, R37, Rc, Rd, or Rc and Rd taken together is optionally substituted by 1 to 3 substituents independently selected from the group consisting of halo, —OH, ═O, C1-C4 alkyl, C1-C4 alkoxy, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C4 alkoxy-C1-C6 alkyl, —CN, —NH2, —NH(C1-C4 alkyl) and —N(C1-C4 alkyl)2;
• X and Z are independently selected from the group consisting of H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl, 5-12 membered heteroaryl, halo, CN, —C(O)Ra, —CO2Ra, —C(O)NRaRb, —SRa, —SORa, —SO2Ra, —SO2NRaRb, —NO2, —NRaRb, —NRaC(O)Rb, —NRaC(O)NRaRb, —NRaC(O)ORa, —NRaSO2Rb, —NRaSO2NRaRb—ORa, —OC(O)Ra or —OC(O)NRaRb;
• wherein each said C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl, or 5-12 membered heteroaryl group is optionally substituted by one or more substituents independently selected from the group consisting of halo, —CN, —C(O)Ra, —CO2Ra, —C(O)NRaRb, —SRa, —SORa, —SO2Ra, —SO2NRaRb, —NO2, —NRaRb, —NRaC(O)Rb, —NRaC(O)NRaRb, —NRaC(O)ORa—NRaSO2Rb, —NRaSO2NRaRb, —ORa, —OC(O)Ra, —OC(O)NRaRb, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl, and 5-12 membered heteroaryl;
• each Ra and Rb is independently H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl or 5-12 membered heteroaryl, where each said C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, 3-12 membered heterocyclyl, C6-C12 aryl and 5-12 membered heteroaryl is optionally substituted by one or more substituents independently selected from the group consisting of halo, C1-C4 alkyl, —OR14, —NR142, —CO2R14, —C(O)NR142, —SO2R14 and —SO2NR142, where each R14 is independently H or C1-C4 alkyl;
• or
• Ra and Rb may be taken together with the N atom to which they are attached to form a 3-12 membered heterocyclyl or 5-12 membered heteroaryl, each optionally containing 1, 2 or 3 additional heteroatoms selected from O, N and S, wherein said heterocyclyl or heteroaryl is optionally substituted by one or more substituents independently selected from the group consisting of halo, —OH, ═O, C1-C4 alkyl, C1-C4 alkoxy, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C4 alkoxy-C1-C6 alkyl, —CN, —NH2, —NH(C1-C4 alkyl) and —N(C1-C4 alkyl)2;
• and
• Y is H, halo, —OH or C1-C4 alkoxy.