Methods and compounds to inhibit enveloped virus release
AssigneesThe Research Foundation for The State University of New York, Northwestern University
InventorsJonathan Leis, Carol Carter
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Abstract
A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.
Claims20
A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell.
A method of inhibiting release of an enveloped virus from a cell, comprising contacting the cell with a compound having an antiviral activity, said antiviral activity comprises:
- (i) inhibiting formation of an associative complex;
- or
- (ii) disrupting formation of an associative complex,
- wherein the associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.
A pharmaceutical composition comprising a compound having an antiviral activity for inhibiting release of an enveloped virus from a cell and optionally a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.