Composition comprising pyrazino-triazine derivatives

A composition, comprising:

• at least one compound selected from the group consisting of a compound represented by Chemical Formula 1 below, an isomer thereof and a pharmaceutically acceptable salt thereof, as an active ingredient,
• wherein the composition comprises a solubilizer and a stabilizer,
• wherein the solubilizer is one or more selected from the group consisting of a saccharide, an alcohol, an acid, a salt and a polymer and the stabilizer including one or more selected from the group consisting of a saccharide, an acid, a salt, an antioxidant, and a polymer:
• wherein R1 is substituted or unsubstituted C3˜C10 aryl, or substituted or unsubstituted C3˜C10 heteroaryl with at least one nitrogen (N) atom;
• R3 is hydrogen, C1˜C6 alkyl, C2˜C6 alkenyl, C2˜C6 alkynyl, C3˜C10 heteroaryl with at least one nitrogen (N) atom, C3˜C10 arylalkyl, or C3˜C10 heteroarylalkyl with at least one nitrogen (N) atom;
• A is hydrogen or C1˜C6 alkyl;
• B is hydrogen or C1˜C6 alkyl;
• X is —O—PO3H2, —O—SO2NH2, carbamate,
• and
• Y is hydrogen, C3˜C10 aryl, C3˜C10 heteroaryl with at least one nitrogen (N) atom, or C1˜C6 alkyl.