Use of docasatrienes, resolvins, and their stable analogs in the treatment of airway diseases and asthma

An isolated compound comprising the formula:

• or pharmaceutically acceptable salts thereof, wherein:
• each of P1, P2 and P3 is independently a hydrogen atom or a protecting group;
• R1 is an optionally substituted alkyl;
• an optionally substituted aryl;
• an optionally substituted alkylaryl, halogen, or a hydrogen atom;
• Z is a —C(O)ORd, —C(O)NRcRc, —C(O)H, —C(NH)NRcRc, —C(S)H, —C(S)ORd, —C(S)NRcRc, or —CN, wherein:
• each Rc is independently a protecting group or Ra, or, alternatively, two Rc are taken together with the nitrogen atom to which they are bonded to form a 5 to 8-membered cycloheteroalkyl or heteroaryl optionally substituted with one or more of the same or different Ra or Rb groups;
• each Rd is independently a protecting group or Ra;
• each Ra is independently a hydrogen atom, (C1-C6) alkyl, (C3-C8) cycloalkyl, cyclohexyl, (C4-C11) cycloalkylalkyl, (C5-C10) aryl, phenyl, (C6-C16) arylalkyl, benzyl, 2-6 membered heteroalkyl, 3-8 membered cycloheteroalkyl, morpholinyl, piperazinyl, homopiperazinyl, piperidinyl, 4-11 membered cycloheteroalkylalkyl, 5-10 membered heteroaryl, or 6-16 membered heteroarylalkyl;
• each Rb is independently a ═O, —ORd, (C1-C3) haloalkyloxy, —OCF3, ═S, —SRd, ═NRd, ═NORd, —NRcRc, halogen, —CF3, —CN, —NC, —OCN, —SCN, —NO, —NO2, ═N2, —N3, —S(O)Rd, —S(O)2Rd, —S(O)2ORd, —S(O)NRcRc, —S(O)2NRcRc, —OS(O)Rd, —OS(O)2Rd, —OS(O)2ORd, —OS(O)2NRcRc, —C(O)Rd, —C(O)ORd, —C(O)NRcRc, —C(NH)NRcRc, —C(NRa)NRcRc, —C(NOH)Ra, —C(NOH)NRcRc, —OC(O)Rd, —OC(O)ORd, —OC(O)NRcRc, —OC(NH)NRcRc, —OC(NRa)NRcRc, —[NHC(O)]nRd, —[NRaC(O)]nRd, —[NHC(O)]nORd, —[NRaC(O)]nORd, —[NHC(O)]nNRcRc, —[NRaC(O)]nNRcRc, —[NHC(NH)]nNRcRc, or -[NRaC(NRa)]nNRcRc;
• and
• each n, independently is an integer from 0 to 3;
• each double bond represents an E or a Z isomer.