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US 2014/0179624 A1Published application
Cytoprotective derivatives of avicin d and methods of making and using thereof
AssigneeResearch Development Foundation
InventorsJordan GUTTERMAN, Valsala HARIDAS, Peter C. MICHELS, Yuri L. KHMELNITSKY, Vadim M. MOZHAEV
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Abstract
Disclosed herein are novel cytoprotective derivatives of avicin D, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising these derivative compounds. Methods and intermediates useful for making the derivatives, and methods of using the derivatives and compositions thereof, including for the treatment of cancer, are also provided.
Claims29
A compound of the formula:
- wherein:
- R1 is:
- hydrogen, a monosaccharide group, a disaccharide group, an oligosaccharide group or a terpenoid group, or
- alkyl(C≦30), alkenyl(C≦30), alkynyl(C≦30), aryl(C≦30), aralkyl(C≦30), acyl(C≦30), or a substituted version of any of these groups;
- R2 is hydroxy, peroxy or oxo;
- R3 is absent or methyl, provided that R3 is absent when the atom to which is bound is part of double bond, further provided that when R3 is absent the atom to which it is bound is part of a double bond;
- R4 is absent or methyl, provided that R4 is absent when the atom to which is bound is part of double bond, further provided that when R4 is absent the atom to which it is bound is part of a double bond;
- and
- R5 is:
- hydrogen, a monosaccharide group, a disaccharide group, an oligosaccharide group or a terpenoid group, or
- alkyl(C≦30), alkenyl(C≦30), alkynyl(C≦30), aryl(C≦30), aralkyl(C≦30), acyl(C≦30), or a substituted version of any of these groups;
- or a pharmaceutically acceptable salt, acetal, ketal or tautomer thereof.
9 more elements
A compound of the formula:
Dependencies are inferred from the claim text.