Peptides that stimulate subcutaneous adipogenesis
AssigneeThe Regents of the University of California
InventorsEVA A. TURLEY, SEYED BAHRAM BAHRAMI, MINA J. BISSELL
Life of this patent
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Abstract
Peptides of 5 to 14 amino acids in length that stimulate subcutaneous adipogenesis and uses thereof are provided.
Claims47
A pharmaceutical or cosmetic composition comprising a pharmaceutically or cosmetically acceptable carrier and a peptide for stimulating subcutaneous adipogenesis, wherein the peptide has a length of 6 to 14 amino acids and comprises a motif having the sequence:
- X1-X2-X3-X4-X5-X6
- wherein
- at least one of X1 and X6 is a positively charged amino acid;
- the other of X1 and X6 is a positively charged amino acid, leucine (L), or alanine (A);
- X2 is serine (S), glutamine (Q), alanine (A), glutamate (E), asparagine (N), proline (P), cysteine (C), lysine (K), aspartate (D), tryptophan (W), methionine (M), or threonine (T);
- X3 is a negatively charged amino acid, alanine (A), glutamine (Q), serine (S), lysine (K), asparagine (N), or threonine (T);
- X4 is isoleucine (I), valine (V), leucine (L), asparagine (N), alanine (A), serine (S), proline (P), threonine (T), or glutamine (Q);
- and X5 is serine (S), aspartate (D), threonine (T), leucine (L), alanine (A), phenylalanine (F), glutamate (E), asparagine (N), glycine (G), arginine (R), glutamine (Q), histidine (H), or isoleucine (I);
- provided that X2 and X5 are not both glutamine (Q);
- and provided that when X1 is arginine (R), X3 is not lysine (K).
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A pharmaceutical or cosmetic composition comprising a pharmaceutically or cosmetically acceptable carrier and a peptide for stimulating subcutaneous adipogenesis, wherein the peptide has a length of 5 to 14 amino acids and comprises a motif having the sequence
- X1-X2-X3-X4-X5-X6
- wherein
- at least one of X1 and X6 is a positively charged amino acid;
- the other of X1 and X6 is a positively charged amino acid, leucine (L) or a conservative substitution therefor, alanine (A) or a conservative substitution therefor, or absent;
- and
- X2-X3-X4-X5 is an amino acid sequence having at least 50% sequence identity with the amino acid sequence SEVS and having a length of 4 to 8 amino acids.
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A pharmaceutical or cosmetic composition comprising a pharmaceutically or cosmetically acceptable carrier and a peptide for stimulating subcutaneous adipogenesis, wherein the peptide has a length of 6 to 13 amino acids and comprises a motif having the sequence:
- X1-X2-X3-X4-X5-X6
- wherein
- X1 is serine (S) or a conservative substitution therefor;
- X2 is a hydrophobic amino acid;
- X3 is any amino acid;
- X4 is a hydrophobic amino acid;
- X5 is serine (S), arginine (R), or a conservative substitution therefor;
- and
- X6 is a charged amino acid;
- provided that X1, X2 and X4 are not all glycine (G);
- and
- provided that X1 is not glutamine (Q).
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A peptide for stimulating subcutaneous adipogenesis, wherein the peptide has a length of 6 to 8 amino acids and comprises a motif having the sequence:
- X1-X2-X3-X4-X5-X6
- wherein
- at least one of X1 and X6 is a positively charged amino acid;
- the other of X1 and X6 is a positively charged amino acid, leucine (L), or alanine (A);
- X2 is serine (S), glutamine (Q), alanine (A), glutamate (E), asparagine (N), proline (P), cysteine (C), lysine (K), aspartate (D), tryptophan (W), methionine (M), or threonine (T);
- X3 is a negatively charged amino acid, alanine (A), glutamine (Q), serine (S), lysine (K), asparagine (N), or threonine (T);
- X4 is isoleucine (I), valine (V), leucine (L), asparagine (N), alanine (A), serine (S), proline (P), threonine (T), or glutamine (Q);
- and X5 is serine (S), aspartate (D), threonine (T), leucine (L), alanine (A), phenylalanine (F), glutamate (E), asparagine (N), glycine (G), arginine (R), glutamine (Q), histidine (H), or isoleucine (I);
- provided that X2 and X5 are not both glutamine (Q);
- and provided that when X1 is arginine (R), X3 is not lysine (K).
Dependencies are inferred from the claim text.