Transferrin-Tumstatin Fusion Protein and Methods For Producing and Using the Same
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsUday B. Kompella, Robert I. Scheinman, Puneet Tyagi
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Abstract
The present invention provides recombinant proteins comprising transferrin that is linked to tumstatin or other antiangiogenic protein and methods for producing and using the same. The present invention also provides an expression system, a plasmid, and a cell that is capable of expressing such recombinant proteins and methods for producing and using the same.
Claims12
A recombinant protein comprising transferrin that is linked to tumstatin.
A method for producing a recombinant protein comprising transferrin that is linked to tumstatin, said method comprising:
- transfecting a recombinant host cell with a recombinant nucleic acid molecule comprising a nucleic acid sequence encoding a recombinant protein comprising transferrin that is linked to tumstatin;
- culturing the transfected host cell under conditions sufficient to produce the recombinant protein comprising transferrin that is linked to tumstatin;
- and
- recovering the recombinant protein as a substantially purified recombinant protein.
A method for treating a clinical condition associated with choroidal neovascularization (CNV) in a subject, said method comprising administering to the subject in need of such a treatment a therapeutically effective amount of a recombinant protein comprising transfferin that is linked to tumstatin.
Dependencies are inferred from the claim text.