Fgf-9 and its use relating to blood vessels
AssigneeThe University of Western Ontario
InventorsGeoffrey J. Pickering, Zengxuan Nong, Matthew Frontini
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Abstract
There is provided a composition for controlling formation and/or stabilization of a blood vessel comprising a first isolated nucleic acid molecule that encodes a FGF-9 polypeptide and optionally one or more isolated nucleic acid molecule that encodes another angiogenic polypeptide. There is provided a composition for controlling formation and/or stabilization of a blood vessel comprising administering an effective amount of a composition comprising an isolated FGF-9 polypeptide and one or more other angiogenic polypeptides. The compositions provided herein may be useful for controlling angiogenesis and/or vasculogenesis.
Claims62
A composition for promoting therapeutic angiogenisis in an animal comprising a first isolated nucleic acid molecule that encodes a FGF-9 polypeptide and a second isolated nucleic acid molecule that encodes an angiogenic polypeptide.
A composition for promoting therapeutic angiogenesis in an animal comprising an isolated FGF-9 polypeptide and one or more other angiogenic polypeptides.
A composition for promoting therapeutic angiogenesis in an animal comprising a recombinant cell producing an isolated FGF-9 polypeptide and another isolated angiogenic polypeptide.
A method of promoting formation of mature blood vessels in a subject comprising administering an effective amount of FGF-9 to the subject.
A method of treating ischemia in a subject comprising administering an effective amount of FGF-9 to the subject.
A use of FGF-9 for preparation of a medicament.
A use of FGF-9 for preparation of a medicament for promoting for on of mature blood vessels in a subject.
A use of FGF-9 for preparation of a medicament for treating ischemia in a subject.
A use of FGF-9 for promoting formation of mature blood vessels in a subject.
A use of FGF-9 for treating ischemia in a subject.
A kit comprising FGF-9, and instructions for administering the composition to a subject.
A kit comprising FGF-9 and a matrix material, and instructions for preparing an in vitro vasculogenesis assay.
An in vitro vasculogenesis assay comprising a matrix material, FGF-9, endothelial cells, smooth muscle cells, and a matrix material for supporting growth and proliferation of all cells.
Use of FGF-9 for stabilization of blood vessels in vitro or in vivo.
The use of FGF-9 for treatment of cancer.
A composition for improving the condition of a blood vessel in an animal, the composition comprising an isolated FGF-9 polypeptide and one or more other angiogenic polypeptides.
Dependencies are inferred from the claim text.