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US 2014/0179599 A1Published application
Stable formulations for parenteral injection of peptide drugs
AssigneeXeris Pharmaceuticals, Inc.
InventorsSteven Prestrelski, John Kinzell
Life of this patent
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Abstract
Stable formulations for parenteral injection of peptide drugs and methods of using such stable formulations are provided. In particular, the present invention provides stable formulations for parenteral injection of glucagon and methods of using such glucagon formulations to treat hypoglycemia, especially severe hypoglycemia in emergency situations.
Claims29
1-98. (canceled)
A method comprising administering a stable solution to a subject, the stable solution comprising:
- (a) a glucagon peptide or a salt thereof that has been dried from a buffer, wherein the glucagon peptide or salt thereof has a pH memory;
- and
- (b) an aprotic polar solvent, wherein the glucagon peptide or salt thereof is reconstituted and solubilized in the aprotic polar solvent in an amount from about 0.1 mg/mL up to the solubility limit of the glucagon peptide or salt thereof, and
- wherein the glucagon peptide or salt thereof maintains the pH memory in the aprotic polar solvent.
1 more element
Dependencies are inferred from the claim text.