Drug discovery methods and platforms
AssigneeFred Hutchinson Cancer Research Center
InventorsJames Olson, Christopher Mehlin, Mark Stroud, Julian Simon, Colin Correnti, Patrick Paddison, Roland Strong, Damon May
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Abstract
Methods and systems for discovering drug candidates are disclosed. Methods and systems can include generating libraries of potential drug candidates (e.g., libraries of peptides) that can be screened to identify sub-libraries of potential drug candidates (e.g., sub-libraries of peptides) having selected pharmacological properties. Methods of making and using peptide libraries are also provided. D-amino acid chlorotoxins and D-amino acid chlorotoxin variants are also provided.
Claims27
A method for identifying drug candidates having a pharmacological property, the method comprising:
- administering, to a subject, a composition comprising a plurality of drug candidates;
- obtaining, from the subject, a sample comprising at least some of the drug candidates in the plurality;
- and
- analyzing the sample to determine the identity of the at least some of the drug candidates having the pharmacological property.
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Dependencies are inferred from the claim text.