Marker sequences for diagnosing prostate cancer, and use thereof
AssigneeProtagen AG
InventorsANGELIKA LUEKING, AXEL KOWALD, HELMUT KLOCKER
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Abstract
The present invention relates to novel marker sequences for prostate carcinoma while excluding inflammatory prostate diseases or diabetes or polymorbidity and relates to their diagnostic use including a method for screening potential active substances for such prostate diseases by means of these marker sequences. The invention furthermore relates to a diagnostic device including such marker sequences for prostate carcinoma, in particular a protein biochip and its use.
Claims11
A method for the diagnosis of prostate carcinoma while excluding inflammatory prostate diseases or diabetes or polymorbidity, comprising determining at least one marker sequence selected from the group SEQ 1-246 and/or SEQ 247-452 or respectively a protein coded thereby or respectively from a partial sequence or fragment thereof on or from a patient to be examined and wherein the marker sequence(s) was/were identified with a method including the
- a. Identification of marker sequence candidates using differential screening with protein biochips from respectively a cDNA expression bank of a patient who has prostate cancer and a subject who does not have prostate cancer,
- b. Validation of the marker sequence candidates by means of samples from patients who have inflammatory prostate disease(s) and/or samples from patients who have diabetes.
A method for risk stratification, or for therapy control of a patient with prostate carcinoma, while excluding inflammatory prostate diseases or diabetes or polymorbidity, comprising determining at least one marker sequence selected from the group SEQ 1-246 and/or SEQ 247-452 or respectively a protein coded thereby or respectively a from partial sequence or fragment thereof on or from a patient to be examined.
Assay, protein biochip comprising an arrangement containing at least one marker sequence of a cDNA respectively selected from the group SEQ 1-246 and/or SEQ 247-452 or respectively a protein coded thereby or respectively from a partial sequence or fragment thereof, characterized in that the marker sequence(s) is/are applied to a solid support and wherein the marker sequence(s) was/were identified with a method including the steps
- a) Identification of marker sequence candidates using differential screening with protein biochips from respectively a cDNA expression bank of a patient who has prostate cancer and a subject who does not have prostate cancer,
- b) Validation of the marker sequence candidates by means of samples from patients who have inflammatory prostate disease(s) and/or samples from patients who have diabetes.
Dependencies are inferred from the claim text.