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US 2014/0179554 A1Published application
Microarrays
AssigneeHutman Diagnostics AG
InventorsMichal Svoboda, Xenia Svoboda
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Abstract
Provided herein are microarrays (protein and/or nucleic acid microarrays) containing an array of spots on a solid substrate, wherein the spots are arranged to reduce the risk of array misalignment and/or to facilitate the visual interpretation of an array image by a human operator. Also provided herein are methods of using such arrays and kits containing such arrays.
Claims25
A nucleic acid microarray comprising an array of spots on a solid substrate, wherein the array of spots includes:
- a plurality of pathogen-specific spots, each pathogen-specific spot containing a pathogen-specific nucleic acid probe immobilized on the solid substrate;
- one or more always-fluorescing spots containing a fluorescent dye immobilized to the solid substrate;
- and
- one or more never-fluorescing spots containing neither a fluorescent dye nor a nucleic acid probe immobilized to the solid substrate;
- wherein the one or more always-fluorescing spots and the one or more never-fluorescing spots are positioned such that the array of spots has neither rotational symmetry nor mirror symmetry.
2 more elements
23-39. (canceled)
41-43. (canceled)
Dependencies are inferred from the claim text.