Methods for identifying inflammatory bowel disease patients with dysplasia or cancer
AssigneeNestec S.A.
InventorsFRANCIS FARRAYE, Fred Princen
Life of this patent
Estimating the term…
Abstract
The present invention provides methods for identifying IBD patients with dysplasia or cancer. In particular embodiments, the methods of the invention may comprise determining the presence or level of at least one or a panel of miRNAs in a sample obtained from an IBD patient to establish a miRNA expression profile, and comparing the miRNA expression profile with one or more pre-established model miRNA expression profiles. The present invention further provides methods for monitoring the efficacy of treatment of IBD patients with dysplasia or cancer.
Claims27
A method for identifying an inflammatory bowel disease (IBD) patient with dysplasia or cancer, the method comprising:
- (a) determining the presence or level of at least one or a plurality of miRNAs in a sample from the patient to establish a miRNA expression profile;
- (b) comparing the miRNA expression profile to one or more pre-established model miRNA expression profiles from a control and/or reference standard;
- and
- (c) identifying dysplasia or cancer in the IBD patient based upon the comparison in step (b).
A method for monitoring the efficacy of treatment of an IBD patient with dysplasia or cancer, the method comprising:
- (a) determining the presence or level of at least one or a plurality of miRNAs in a first sample from the patient to establish a first miRNA expression profile, wherein the first sample is obtained before treatment;
- (b) determining the presence or level of the identical miRNAs in a second sample from the patient to establish a second miRNA expression profile, wherein the second sample is obtained during or after treatment;
- (c) comparing the first miRNA expression profile to the second miRNA expression profile;
- and
- (d) monitoring the efficacy of treatment for the IBD patient based upon the comparison in step (c).
Dependencies are inferred from the claim text.